TY - BOOK ID - 50678530 TI - New research in obsessive-compulsive disorder and major depression AU - Aouizerate, Bruno AU - Haffen, Emmanuel PY - 2019 SN - 3039210912 3039210904 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - n/a KW - i-health KW - olfaction KW - psychiatry KW - obsession KW - obsessive–compulsive disorder KW - transcranial direct current stimulation KW - ecological momentary assessment KW - Streptococcus pyogenes KW - cytokines KW - immunology KW - compulsion KW - cognition KW - nosography KW - pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS) KW - symptoms networks KW - brain stimulation KW - neuromodulation KW - OCD KW - m-health KW - categorizations KW - ecological momentary intervention KW - fictional case study KW - pediatric acute-onset neuropsychiatric syndrome (PANS) KW - Toxoplasma gondii KW - tDCS KW - therapeutic tool KW - depression KW - markers KW - quality of life KW - Tourette syndrome KW - Obsessive-compulsive disorder. KW - Depression, Mental. KW - Dejection KW - Depression, Unipolar KW - Depressive disorder KW - Depressive psychoses KW - Melancholia KW - Mental depression KW - Unipolar depression KW - Affective disorders KW - Neurasthenia KW - Neuroses KW - Manic-depressive illness KW - Melancholy KW - Sadness KW - Compulsive disorder KW - Fixed ideas KW - Obsession (Psychology) KW - Obsessive-compulsive neuroses KW - Obsessive-compulsive neurosis KW - OCD (Disease) KW - Compulsive behavior KW - Bipolar disorder KW - obsessive-compulsive disorder UR - https://www.unicat.be/uniCat?func=search&query=sysid:50678530 AB - Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD. ER -