TY - BOOK ID - 50115725 TI - Design and optimization in organic synthesis PY - 1992 VL - 8 SN - 1281754609 9786611754600 0080868355 044489201X PB - Amsterdam ; New York : Elsevier, DB - UniCat KW - Chemical reaction, Conditions and laws of. KW - Organic compounds KW - Synthesis. KW - Chemistry, Organic KW - Chemistry, Synthetic organic KW - Organic synthesis (Chemistry) KW - Synthetic organic chemistry KW - Conditions and laws of chemical reaction KW - Reaction, Conditions and laws of (Chemistry) KW - Chemistry, Physical and theoretical KW - Physical laws KW - Synthesis KW - Composés organiques KW - Synthèse UR - https://www.unicat.be/uniCat?func=search&query=sysid:50115725 AB - This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient method ER -