TY - BOOK ID - 49869312 TI - Biochemistry of collagens, laminins and elastin : structure, function and biomarkers PY - 2019 SN - 0128170697 0128170689 9780128170694 9780128170687 PB - London : Academic Press, DB - UniCat KW - Cytoskeletal proteins KW - Purification KW - Collagen. KW - Cytoskeletal Proteins. KW - Avicon KW - Avitene KW - Collagen Felt KW - Collagen Fleece KW - Collagenfleece KW - Collastat KW - Dermodress KW - Microfibril Collagen Hemostat KW - Pangen KW - Zyderm KW - alpha-Collagen KW - Collagen Hemostat, Microfibril KW - alpha Collagen KW - Connective Tissue KW - Proteins, Cytoskeletal KW - Cytoskeleton KW - Collogen KW - Extracellular matrix proteins KW - Connective tissues KW - Structural proteins KW - Proteins UR - https://www.unicat.be/uniCat?func=search&query=sysid:49869312 AB - There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease.-- ER -