TY - BOOK ID - 4868308 TI - Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease AU - Nguyen, Hoa Huu Phuc. AU - Cenci, M. Angela. PY - 2015 SN - 9783662463444 3662463431 9783662463437 366246344X PB - Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, DB - UniCat KW - Biomedicine. KW - Neurosciences. KW - Human Genetics. KW - Neurobiology. KW - Cell Biology. KW - Medicine. KW - Human genetics. KW - Cytology. KW - Médecine KW - Génétique humaine KW - Neurosciences KW - Cytologie KW - Neurobiologie KW - Biology KW - Parkinsonian Disorders KW - Cognition Disorders KW - Basal Ganglia Diseases KW - Dementia KW - Investigative Techniques KW - Heredodegenerative Disorders, Nervous System KW - Behavior KW - Neurodegenerative Diseases KW - Chorea KW - Behavior and Behavior Mechanisms KW - Delirium, Dementia, Amnestic, Cognitive Disorders KW - Movement Disorders KW - Biological Science Disciplines KW - Brain Diseases KW - Nervous System Diseases KW - Dyskinesias KW - Genetic Diseases, Inborn KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Central Nervous System Diseases KW - Mental Disorders KW - Psychiatry and Psychology KW - Natural Science Disciplines KW - Congenital, Hereditary, and Neonatal Diseases and Abnormalities KW - Diseases KW - Disciplines and Occupations KW - Parkinson Disease KW - Huntington Disease KW - Behavior, Animal KW - Models, Animal KW - Neurobiology KW - Medicine KW - Health & Biological Sciences KW - Neurology KW - Neurobiology, Cellular KW - Neurobiology, Molecular KW - Cellular Neurobiology KW - Molecular Neurobiology KW - Experimental Animal Models KW - Laboratory Animal Models KW - Animal Model KW - Animal Model, Experimental KW - Animal Model, Laboratory KW - Animal Models KW - Animal Models, Experimental KW - Animal Models, Laboratory KW - Experimental Animal Model KW - Laboratory Animal Model KW - Model, Animal KW - Model, Experimental Animal KW - Model, Laboratory Animal KW - Models, Experimental Animal KW - Models, Laboratory Animal KW - Animal Behavior KW - Animal Behaviors KW - Behaviors, Animal KW - Akinetic-Rigid Variant of Huntington Disease KW - Chorea, Chronic Progressive Hereditary (Huntington) KW - Chronic Progressive Hereditary Chorea (Huntington) KW - Huntington Chronic Progressive Hereditary Chorea KW - Huntington Disease, Akinetic-Rigid Variant KW - Huntington Disease, Juvenile KW - Huntington Disease, Juvenile-Onset KW - Huntington Disease, Late Onset KW - Huntington's Chorea KW - Huntington's Disease KW - Juvenile-Onset Huntington Disease KW - Late-Onset Huntington Disease KW - Progressive Chorea, Chronic Hereditary (Huntington) KW - Progressive Chorea, Hereditary, Chronic (Huntington) KW - Huntington Chorea KW - Juvenile Huntington Disease KW - Akinetic Rigid Variant of Huntington Disease KW - Chorea, Huntington KW - Chorea, Huntington's KW - Huntington Disease, Akinetic Rigid Variant KW - Huntington Disease, Juvenile Onset KW - Huntington Disease, Late-Onset KW - Juvenile Onset Huntington Disease KW - Late Onset Huntington Disease KW - Idiopathic Parkinson's Disease KW - Lewy Body Parkinson's Disease KW - Parkinson Disease, Idiopathic KW - Parkinson's Disease KW - Parkinson's Disease, Idiopathic KW - Parkinson's Disease, Lewy Body KW - Idiopathic Parkinson Disease KW - Lewy Body Parkinson Disease KW - Paralysis Agitans KW - Primary Parkinsonism KW - Parkinsonism, Primary KW - Disorders, Congenital KW - Congenital Disorders KW - Neonatal Diseases and Abnormalities KW - Congenital Disorder KW - Disorder, Congenital KW - Natural Sciences KW - Physical Sciences KW - Discipline, Natural Science KW - Disciplines, Natural Science KW - Natural Science KW - Natural Science Discipline KW - Physical Science KW - Science, Natural KW - Science, Physical KW - Sciences, Natural KW - Sciences, Physical KW - Behavior Disorders KW - Diagnosis, Psychiatric KW - Mental Disorders, Severe KW - Psychiatric Diagnosis KW - Disorder, Mental KW - Disorder, Severe Mental KW - Disorders, Behavior KW - Disorders, Mental KW - Disorders, Severe Mental KW - Mental Disorder KW - Mental Disorder, Severe KW - Severe Mental Disorder KW - Severe Mental Disorders KW - CNS Diseases KW - Central Nervous System Disorders KW - CNS Disease KW - Genetic Diseases KW - Genetic Disorders KW - Hereditary Disease KW - Inborn Genetic Diseases KW - Single-Gene Defects KW - Hereditary Diseases KW - Defect, Single-Gene KW - Defects, Single-Gene KW - Disease, Genetic KW - Disease, Hereditary KW - Disease, Inborn Genetic KW - Diseases, Genetic KW - Diseases, Hereditary KW - Diseases, Inborn Genetic KW - Disorder, Genetic KW - Disorders, Genetic KW - Genetic Disease KW - Genetic Disease, Inborn KW - Genetic Disorder KW - Inborn Genetic Disease KW - Single Gene Defects KW - Single-Gene Defect KW - Nervous System Disorders KW - Neurological Disorders KW - Neurologic Disorders KW - Disease, Nervous System KW - Diseases, Nervous System KW - Disorder, Nervous System KW - Disorder, Neurologic KW - Disorder, Neurological KW - Disorders, Nervous System KW - Disorders, Neurologic KW - Disorders, Neurological KW - Nervous System Disease KW - Nervous System Disorder KW - Neurologic Disorder KW - Neurological Disorder KW - Brain Disorders KW - CNS Disorders, Intracranial KW - Central Nervous System Disorders, Intracranial KW - Central Nervous System Intracranial Disorders KW - Encephalon Diseases KW - Encephalopathy KW - Intracranial CNS Disorders KW - Intracranial Central Nervous System Disorders KW - Brain Disease KW - Brain Disorder KW - CNS Disorder, Intracranial KW - Encephalon Disease KW - Encephalopathies KW - Intracranial CNS Disorder KW - Biologic Sciences KW - Biological Science KW - Science, Biological KW - Sciences, Biological KW - Biological Sciences KW - Life Sciences KW - Biologic Science KW - Biological Science Discipline KW - Discipline, Biological Science KW - Disciplines, Biological Science KW - Life Science KW - Science Discipline, Biological KW - Science Disciplines, Biological KW - Science, Biologic KW - Science, Life KW - Sciences, Biologic KW - Sciences, Life KW - Movement Disorder Syndromes KW - Oral Dyskinesia KW - Dyskinesia Syndromes KW - Etat Marbre KW - Status Marmoratus KW - Dyskinesia Syndrome KW - Dyskinesia, Oral KW - Dyskinesias, Oral KW - Movement Disorder KW - Movement Disorder Syndrome KW - Oral Dyskinesias KW - Nonpsychotic Organic Brain Syndrome KW - Clerambault Syndrome KW - Kandinsky Syndrome KW - Mental Disorders, Organic KW - Organic Brain Syndrome, Nonpsychotic KW - Organic Mental Disorders KW - Organic Mental Disorders, Psychotic KW - Psychoses, Traumatic KW - Disorder, Neurocognitive KW - Disorders, Neurocognitive KW - Disorders, Organic Mental KW - Mental Disorder, Organic KW - Neurocognitive Disorder KW - Organic Mental Disorder KW - Traumatic Psychoses KW - Neuroscience KW - Chorea Disorders KW - Chorea Syndromes KW - Chorea, Benign Hereditary KW - Chorea, Chronic Progressive KW - Chorea, Rheumatic KW - Chorea, Senile KW - Chorea, Sydenham KW - Choreatic Syndromes KW - Choreic Movement KW - Dyskinesias, Paroxysmal KW - Hereditary Chorea KW - Hereditary Progressive Chorea Without Dementia KW - Paroxysmal Dyskinesias KW - Rheumatic Chorea KW - Senile Chorea KW - St. Vitus's Dance KW - Sydenham Chorea KW - Sydenham's Chorea KW - Choreatic Disorders KW - Choreiform Movement KW - Benign Hereditary Chorea KW - Benign Hereditary Choreas KW - Chorea Disorder KW - Chorea Syndrome KW - Chorea, Hereditary KW - Chorea, Sydenham's KW - Choreas KW - Choreas, Benign Hereditary KW - Choreas, Chronic Progressive KW - Choreas, Hereditary KW - Choreas, Rheumatic KW - Choreas, Senile KW - Choreas, Sydenham KW - Choreatic Disorder KW - Choreatic Syndrome KW - Choreic Movements KW - Choreiform Movements KW - Chronic Progressive Chorea KW - Chronic Progressive Choreas KW - Disorder, Chorea KW - Disorder, Choreatic KW - Disorders, Chorea KW - Disorders, Choreatic KW - Dyskinesia, Paroxysmal KW - Hereditary Chorea, Benign KW - Hereditary Choreas KW - Hereditary Choreas, Benign KW - Movement, Choreic KW - Movement, Choreiform KW - Movements, Choreic KW - Movements, Choreiform KW - Paroxysmal Dyskinesia KW - Progressive Chorea, Chronic KW - Progressive Choreas, Chronic KW - Rheumatic Choreas KW - Senile Choreas KW - St. Vitus Dance KW - St. Vitus's Dances KW - St. Vituss Dance KW - Sydenham Choreas KW - Sydenhams Chorea KW - Syndrome, Chorea KW - Syndrome, Choreatic KW - Syndromes, Chorea KW - Syndromes, Choreatic KW - Degenerative Diseases, Central Nervous System KW - Degenerative Diseases, Neurologic KW - Degenerative Diseases, Spinal Cord KW - Degenerative Neurologic Diseases KW - Degenerative Neurologic Disorders KW - Nervous System Degenerative Diseases KW - Neurodegenerative Disorders KW - Neurologic Degenerative Conditions KW - Neurologic Degenerative Diseases KW - Neurologic Diseases, Degenerative KW - Degenerative Diseases, Nervous System KW - Degenerative Condition, Neurologic KW - Degenerative Conditions, Neurologic KW - Degenerative Neurologic Disease KW - Degenerative Neurologic Disorder KW - Neurodegenerative Disease KW - Neurodegenerative Disorder KW - Neurologic Degenerative Condition KW - Neurologic Degenerative Disease KW - Neurologic Disease, Degenerative KW - Neurologic Disorder, Degenerative KW - Neurologic Disorders, Degenerative KW - Acceptance Process KW - Acceptance Processes KW - Behaviors KW - Process, Acceptance KW - Processes, Acceptance KW - Degenerative Hereditary Diseases, Nervous System KW - Hereditary Neurodegenerative Diseases KW - Hereditary-Degenerative Disorders, Nervous System KW - Nervous System Degenerative Hereditary Diseases KW - Nervous System Hereditary Degenerative Diseases KW - Degenerative Disease, Nervous System, Hereditary KW - Degenerative Hereditary Disorders, Nervous System KW - Hereditary Diseases, Neurodegenerative KW - Nervous System Diseases, Degenerative, Hereditary KW - Neurodegenerative Diseases, Hereditary KW - Disease, Hereditary Neurodegenerative KW - Disease, Neurodegenerative Hereditary KW - Diseases, Hereditary Neurodegenerative KW - Diseases, Neurodegenerative Hereditary KW - Hereditary Degenerative Disorders, Nervous System KW - Hereditary Disease, Neurodegenerative KW - Hereditary Neurodegenerative Disease KW - Neurodegenerative Disease, Hereditary KW - Neurodegenerative Hereditary Disease KW - Neurodegenerative Hereditary Diseases KW - Investigative Technics KW - Investigative Technic KW - Investigative Technique KW - Technic, Investigative KW - Technics, Investigative KW - Technique, Investigative KW - Techniques, Investigative KW - Amentia KW - Familial Dementia KW - Senile Paranoid Dementia KW - Amentias KW - Dementia, Familial KW - Dementias KW - Dementias, Familial KW - Dementias, Senile Paranoid KW - Familial Dementias KW - Paranoid Dementia, Senile KW - Paranoid Dementias, Senile KW - Senile Paranoid Dementias KW - Basal Ganglia Disorders KW - Lenticulostriate Disorders KW - Extrapyramidal Disorders KW - Basal Ganglia Disease KW - Basal Ganglia Disorder KW - Extrapyramidal Disorder KW - Lenticulostriate Disorder KW - Overinclusion KW - Disorder, Cognition KW - Disorders, Cognition KW - Autosomal Dominant Juvenile Parkinson Disease KW - Autosomal Dominant Juvenile Parkinsonism KW - Autosomal Dominant Parkinsonism KW - Autosomal Recessive Juvenile Parkinson Disease KW - Autosomal Recessive Parkinsonism KW - Autosomal Recesssive Juvenile Parkinsonism KW - Chromosome 6-Linked Autosomal Recessive Parkinsonism KW - Experimental Parkinson Disease KW - Experimental Parkinsonism KW - Experimental Parkinsonism, MPTP-Induced KW - Familial Parkinson Disease, Autosomal Recessive KW - Juvenile Parkinson Disease KW - Juvenile Parkinson Disease, Autosomal Dominant KW - Juvenile Parkinson Disease, Autosomal Recessive KW - Juvenile Parkinsonism, Autosomal Dominant KW - Juvenile Parkinsonism, Autosomal Recessive KW - MPTP-Induced Experimental Parkinsonism KW - Parkinson Disease 2 KW - Parkinson Disease 2, Autosomal Recessive Juvenile KW - Parkinson Disease Autosomal Recessive, Early Onset KW - Parkinson Disease, Autosomal Dominant. Juvenile KW - Parkinson Disease, Experimental KW - Parkinson Disease, Familial, Autosomal Recessive KW - Parkinson Disease, Juvenile KW - Parkinson Disease, Juvenile, Autosomal Dominant KW - Parkinson Disease, Juvenile, Autosomal Recessive KW - Parkinsonian Diseases KW - Parkinsonian Syndromes KW - Parkinsonism, Early Onset, with Diurnal Fluctuation KW - Parkinsonism, Early-Onset, With Diurnal Fluctuation KW - Parkinsonism, Juvenile, Autosomal Dominant KW - Parkinsonism, Juvenile, Autosomal Recessive KW - Familial Juvenile Parkinsonism KW - Parkinsonian Syndrome KW - Parkinsonism KW - Parkinsonism, Experimental KW - Parkinsonism, Juvenile KW - Ramsay Hunt Paralysis Syndrome KW - Chromosome 6 Linked Autosomal Recessive Parkinsonism KW - Diseases, Experimental Parkinson KW - Dominant Parkinsonism, Autosomal KW - Experimental Parkinson Diseases KW - Experimental Parkinsonism, MPTP Induced KW - Experimental Parkinsonisms KW - Juvenile Parkinsonism KW - Juvenile Parkinsonism, Familial KW - Juvenile Parkinsonisms KW - MPTP Induced Experimental Parkinsonism KW - Parkinson Diseases, Experimental KW - Parkinsonism, Autosomal Dominant KW - Parkinsonism, Autosomal Recessive KW - Parkinsonism, Familial Juvenile KW - Parkinsonism, MPTP-Induced Experimental KW - Parkinsonisms, Experimental KW - Parkinsonisms, Juvenile KW - Recessive Parkinsonism, Autosomal KW - Abnormal Movements KW - Hemiballism KW - Linguofacial Dyskinesia KW - Oral-facial Dyskinesia KW - Tardive Oral Dyskinesia KW - Asterixis KW - Ballismus KW - Hemiballismus KW - Involuntary Movements KW - Lingual-Facial-Buccal Dyskinesia KW - Orofacial Dyskinesia KW - Abnormal Movement KW - Dyskinesia KW - Dyskinesia, Lingual-Facial-Buccal KW - Dyskinesia, Linguofacial KW - Dyskinesia, Oral-facial KW - Dyskinesia, Orofacial KW - Dyskinesias, Lingual-Facial-Buccal KW - Dyskinesias, Linguofacial KW - Dyskinesias, Oral-facial KW - Dyskinesias, Orofacial KW - Involuntary Movement KW - Lingual Facial Buccal Dyskinesia KW - Lingual-Facial-Buccal Dyskinesias KW - Linguofacial Dyskinesias KW - Movement, Abnormal KW - Movement, Involuntary KW - Movements, Abnormal KW - Movements, Involuntary KW - Oral facial Dyskinesia KW - Oral-facial Dyskinesias KW - Orofacial Dyskinesias KW - Tardive Oral Dyskinesias KW - Cell biology. KW - Neural sciences KW - Neurological sciences KW - Medical sciences KW - Nervous system KW - Genetics KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Huntington's disease. KW - Parkinson's disease. KW - Diseases. KW - Chronic progressive chorea KW - Chronic progressive hereditary chorea KW - Degenerative chorea KW - HC (Disease) KW - HD (Disease) KW - Hereditary chorea KW - Huntington chorea KW - Huntington chronic progressive hereditary chorea KW - Huntington disease KW - Huntington's chorea KW - Lund-Huntington chorea KW - Microcellular striatal syndrome KW - Progressive hereditary chorea, Chronic KW - Genetic disorders KW - Medical neurology KW - Nerves KW - Neurologic disorders KW - Neurological disorders KW - Neuropathology KW - Palsy, Shaking KW - Paralysis agitans KW - Parkinson disease KW - Shaking palsy KW - Brain KW - Extrapyramidal disorders KW - Degeneration UR - https://www.unicat.be/uniCat?func=search&query=sysid:4868308 AB - Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to cause familial forms of PD. Following these genetic discoveries, a variety of genetic disease models were generated, providing completely novel opportunities to explore the neurobiological basis of HD and PD. Genetic models allow us to study the earliest manifestations of the diseases both behaviorally and neuropathologically, and provide tools to probe molecular pathways of neurodegeneration. Additionally, neurotoxic animal models allow us to reproduce neurochemical and cellular events of great pathophysiological importance. In the PD field, neurotoxic animal models remain the preferred option to reproduce symptomatic features of the human disease that are responsive to dopaminergic pharmacotherapies. In addition, neurotoxic PD models are often used to investigate pathways of mitochondrial dysfunction, oxidative stress, and neuroinflammation. This book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders. ER -