TY - BOOK ID - 4867594 TI - Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing PY - 2015 SN - 9783658101619 3658101601 9783658101602 365810161X PB - Wiesbaden : Springer Fachmedien Wiesbaden : Imprint: Springer Spektrum, DB - UniCat KW - Biomedicine. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - Medicinal Chemistry. KW - Medicine. KW - Oncology. KW - Toxicology. KW - Biochemistry. KW - Médecine KW - Cancérologie KW - Toxicologie KW - Biochimie KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Drug monitoring. KW - Cisplatin. KW - Cancer cells KW - Treatment. KW - Cis-platinum KW - Diamminedichloroplatinum KW - Dichlorodiamine platinum KW - Dichlorodiammineplatinum KW - Platinum diamminedichloride KW - Drugs KW - Monitoring, Drug KW - Therapeutic drug monitoring KW - Monitoring KW - Cancer research. KW - Pharmacology. KW - Medicinal chemistry. KW - Alkylating agents KW - Antineoplastic agents KW - Chlorides KW - Coordination compounds KW - Metal-ammonia compounds KW - Platinum compounds KW - Patient monitoring KW - Cells KW - Pathology, Cellular KW - Analysis KW - Testing KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Medical sciences KW - Chemicals KW - Pharmacology KW - Poisoning KW - Poisons KW - Tumors KW - Composition KW - Toxicology KW - Chemistry, Medical and pharmaceutical KW - Chemistry, Pharmaceutical KW - Drug chemistry KW - Medical chemistry KW - Medicinal chemistry KW - Pharmacochemistry KW - Drug effects KW - Medical pharmacology KW - Chemotherapy KW - Pharmacy KW - Cancer research KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:4867594 AB - Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion. Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents – Effects Measured in Real Time Metabolism of Cancer Cells Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism. ER -