TY - BOOK ID - 4865569 TI - Metal Response in Cupriavidus metallidurans : Volume II: Insights into the Structure-Function Relationship of Proteins AU - Vandenbussche, Guy. AU - Mergeay, Max. AU - Van Houdt, Rob. PY - 2015 SN - 9783319206240 3319206230 9783319206233 3319206249 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Chemistry. KW - Applied Microbiology. KW - Microbiology. KW - Biogeosciences. KW - Life sciences. KW - Chimie KW - Microbiologie KW - Sciences de la vie KW - Carrier proteins. KW - Metal ions. KW - Proteins -- Structure. KW - Biology KW - Health & Biological Sciences KW - Microbiology & Immunology KW - Proteins KW - Structure. KW - Binding proteins KW - Transport proteins KW - Geobiology. KW - Ions KW - Biological transport KW - Protein binding KW - Microbial biology KW - Microorganisms KW - Monograph KW - Earth sciences KW - Biosphere UR - https://www.unicat.be/uniCat?func=search&query=sysid:4865569 AB - This book is the second volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this second volume, the structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury. In addition, the first volume sketches the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. It provides a detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands. ER -