TY - BOOK ID - 4862685 TI - ADAMTS13 : Biology and Disease PY - 2015 SN - 9783319087177 3319087169 9783319087160 3319087177 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Life Sciences. KW - Proteomics. KW - Hematology. KW - Cell Biology. KW - Life sciences. KW - Cytology. KW - Sciences de la vie KW - Hématologie KW - Protéomique KW - Cytologie KW - Thrombotic thrombocytopenic purpura. KW - Von Willebrand disease. KW - Biochemistry KW - Chemistry KW - Physical Sciences & Mathematics KW - Disseminated arteriolar-capillary platelet thrombosis KW - Febrile pleiochromic anemia KW - Microangiopathic hemolytic anemia KW - Moschcowitz disease KW - Moschcowitz syndrome KW - Moschcowitz's disease KW - Platelet thrombosis KW - Thrombotic microangiopathic hemolytic anemia KW - Thrombotic microangiopathy KW - Thrombotic thrombocytic anemia KW - Thrombotic thrombohemolytic purpura KW - TTP (Disease) KW - Angiohemophilia KW - Hemophilia, Vascular KW - Hereditary pseudohemophilia KW - Pseudohemophilia, Hereditary KW - Vascular hemophilia KW - Von Willebrand's disease KW - Willebrand syndrome KW - Willebrand's syndrome KW - Cell biology. KW - Hemolytic anemia KW - Thrombopenic purpura KW - Thrombosis KW - Blood coagulation disorders KW - Genetic disorders KW - Hemorrhagic diseases KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Haematology KW - Internal medicine KW - Blood KW - Molecular biology KW - Proteins KW - Diseases UR - https://www.unicat.be/uniCat?func=search&query=sysid:4862685 AB - This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases. ER -