TY - BOOK ID - 4862163 TI - BRAF Targets in Melanoma : Biological Mechanisms, Resistance, and Drug Discovery PY - 2015 SN - 9781493921430 1493921428 9781493921423 1493921436 PB - New York, NY : Springer New York : Imprint: Humana, DB - UniCat KW - Biomedicine. KW - Cancer Research. KW - Molecular Medicine. KW - Medical Microbiology. KW - Pharmacology/Toxicology. KW - Medicine. KW - Oncology. KW - Microbiology. KW - Toxicology. KW - Médecine KW - Cancérologie KW - Microbiologie KW - Toxicologie KW - Melanoma KW - raf Kinases KW - Enzyme Inhibitors KW - Therapeutics KW - Neuroendocrine Tumors KW - Nevi and Melanomas KW - Biology KW - Investigative Techniques KW - Biological Science Disciplines KW - Molecular Mechanisms of Pharmacological Action KW - Proto-Oncogene Proteins KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Neuroectodermal Tumors KW - MAP Kinase Kinase Kinases KW - Neoplasms by Histologic Type KW - Neoplasms, Germ Cell and Embryonal KW - Pharmacologic Actions KW - Intracellular Signaling Peptides and Proteins KW - Protein-Serine-Threonine Kinases KW - Neoplasms, Nerve Tissue KW - Oncogene Proteins KW - Natural Science Disciplines KW - Neoplasms KW - Protein Kinases KW - Neoplasm Proteins KW - Chemical Actions and Uses KW - Diseases KW - Peptides KW - Proteins KW - Disciplines and Occupations KW - Amino Acids, Peptides, and Proteins KW - Chemicals and Drugs KW - Phosphotransferases (Alcohol Group Acceptor) KW - Phosphotransferases KW - Transferases KW - Enzymes KW - Enzymes and Coenzymes KW - Molecular Targeted Therapy KW - Drug Therapy KW - Proto-Oncogene Proteins B-raf KW - Genetics KW - Protein Kinase Inhibitors KW - Methods KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Drug delivery systems. KW - Treatment. KW - Delivery systems, Drug KW - Drug administration technology KW - Drug delivery technology KW - Drugs KW - Malignant melanoma KW - Melanocytic tumor KW - Delivery systems KW - Cancer research. KW - Medical microbiology. KW - Molecular biology. KW - Pharmacology. KW - Pharmaceutical technology KW - Cancer KW - Neuroendocrine tumors KW - Chemicals KW - Pharmacology KW - Poisoning KW - Poisons KW - Microbial biology KW - Microorganisms KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Tumors KW - Toxicology KW - Health Workforce KW - Drug effects KW - Medical pharmacology KW - Chemotherapy KW - Pharmacy KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Cancer research KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:4862163 AB - This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma. ER -