TY - BOOK ID - 48211615 TI - Fc Mediated Activity of Antibodies : Structural and Functional Diversity AU - Ravetch, Jeffrey V. AU - Nimmerjahn, Falk. PY - 2019 SN - 3030310531 3030310523 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Fc receptors. KW - Immunology. KW - Oncology. KW - Emerging infectious diseases. KW - Cancer Research. KW - Infectious Diseases. KW - Emerging infections KW - New infectious diseases KW - Re-emerging infectious diseases KW - Reemerging infectious diseases KW - Communicable diseases KW - Tumors KW - Immunobiology KW - Life sciences KW - Serology KW - Cancer research. KW - Infectious diseases. KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:48211615 AB - This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology. ER -