TY - BOOK ID - 46171280 TI - Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management AU - De León-Crutchlow, Diva D. AU - Stanley, Charles A. PY - 2019 SN - 3030029611 3030029603 PB - Cham : Springer International Publishing : Imprint: Humana, DB - UniCat KW - Endocrinology. KW - Pediatrics. KW - Insulin KW - Secretion. KW - Hormones KW - Hypoglycemic agents KW - Pancreas KW - Proinsulin KW - Secretions KW - Paediatrics KW - Pediatric medicine KW - Medicine KW - Children KW - Internal medicine KW - Diseases KW - Health and hygiene KW - Endocrinology . UR - https://www.unicat.be/uniCat?func=search&query=sysid:46171280 AB - This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter. Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists. ER -