TY - BOOK ID - 33239166 TI - Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins PY - 2018 SN - 3030008533 3030008525 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Zinc-finger proteins. KW - Zinc-finger proteins KW - Gold compounds. KW - Inhibitors. KW - Auric compounds KW - Aurous compounds KW - Chemicals KW - Zinc fingers KW - Zinc proteins KW - Chemistry, inorganic. KW - Chemistry, Organic. KW - RNA-ligand interactions. KW - Mass spectrometry. KW - Bioorganic chemistry. KW - Immunology. KW - Inorganic Chemistry. KW - Organometallic Chemistry. KW - Protein-Ligand Interactions. KW - Mass Spectrometry. KW - Bioorganic Chemistry. KW - Immunobiology KW - Life sciences KW - Serology KW - Bio-organic chemistry KW - Biological organic chemistry KW - Biochemistry KW - Chemistry, Organic KW - Mass spectra KW - Mass spectrograph KW - Mass spectroscopy KW - Mass spectrum analysis KW - Mass (Physics) KW - Nuclear spectroscopy KW - Spectrum analysis KW - Organic chemistry KW - Chemistry KW - Inorganic chemistry KW - Inorganic compounds KW - Inorganic chemistry. KW - Organometallic chemistry . KW - Proteins . KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Chemistry, Organometallic KW - Metallo-organic chemistry UR - https://www.unicat.be/uniCat?func=search&query=sysid:33239166 AB - This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling. ER -