TY - BOOK ID - 32842060 TI - Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA PY - 2018 SN - 9811087466 9811087458 PB - Singapore : Springer Singapore : Imprint: Springer, DB - UniCat KW - DNA. KW - Molecular recognition. KW - Chemistry. KW - Bioorganic chemistry. KW - Nucleic acids. KW - Regenerative medicine. KW - Tissue engineering. KW - Bioorganic Chemistry. KW - Nucleic Acid Chemistry. KW - Regenerative Medicine/Tissue Engineering. KW - Biomolecular recognition KW - Recognition, Molecular KW - Ligand binding (Biochemistry) KW - Molecular biology KW - Deoxyribonucleic acid KW - Desoxyribonucleic acid KW - Thymonucleic acid KW - TNA (Nucleic acid) KW - Deoxyribose KW - Nucleic acids KW - Genes KW - Polynucleotides KW - Biomolecules KW - Bio-organic chemistry KW - Biological organic chemistry KW - Biochemistry KW - Chemistry, Organic KW - Biomedical engineering KW - Regenerative medicine KW - Tissue culture KW - Medicine KW - Regeneration (Biology) UR - https://www.unicat.be/uniCat?func=search&query=sysid:32842060 AB - In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book. . ER -