TY - BOOK ID - 32840952 TI - Regulation of Signal Transduction in Human Cell Research AU - Shinomiya, Nariyoshi. AU - Kataoka, Hiroaki. AU - Xie, Qian. PY - 2018 SN - 9811072965 9811072957 PB - Singapore : Springer Singapore : Imprint: Springer, DB - UniCat KW - Cellular signal transduction. KW - Medicine. KW - Cancer research. KW - Oncology. KW - Medical biochemistry. KW - Medicine & Public Health. KW - Medical Biochemistry. KW - Cancer Research. KW - Medical biochemistry KW - Pathobiochemistry KW - Pathological biochemistry KW - Biochemistry KW - Pathology KW - Tumors KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Physicians KW - Cellular information transduction KW - Information transduction, Cellular KW - Signal transduction, Cellular KW - Bioenergetics KW - Cellular control mechanisms KW - Information theory in biology KW - Oncology . KW - Biochemistry. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Composition UR - https://www.unicat.be/uniCat?func=search&query=sysid:32840952 AB - This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases. ER -