TY - BOOK ID - 31331690 TI - Quantitative structure-activity relationship AU - Fatma Kandemirli AU - Kandemirli, Fatma PY - 2017 SN - 9535134108 9535134094 9535146807 PB - IntechOpen DB - UniCat KW - QSAR (Biochemistry) KW - Quantitative structure-activity relationships (Biochemistry) KW - Structure-activity relationships (Biochemistry) KW - Life Sciences KW - Genetics and Molecular Biology KW - Chemical Biology KW - Biochemistry KW - Bioorganic Chemistry UR - https://www.unicat.be/uniCat?func=search&query=sysid:31331690 AB - The book, which is related to QSAR in sciences, is divided into five main chapters. The first chapter is the Introductory chapter. The second chapter aims to provide an update of the recent advances in the field of rational design of PDE inhibitors. The third chapter includes designing a series of peptidic inhibitors that possessed a substrate transition-state analog and evaluating the structure-activity relationship of the designed inhibitors, based on docking and scoring, using the docking simulation software Molecular Operating Environment. The aim of the forth chapter is to develop structure-property relationships for the qualitative and quantitative prediction of the reverse-phase liquid chromatographic retention times of chlorogenic acids. The final chapter aims to determine the model of interactions between the natural compounds with anti-inflammatory molecular target by molecular docking analysis. ER -