TY - BOOK ID - 31331148 TI - Vaccines AU - Hassan Hemeg AU - Afrin, Farhat PY - 2017 SN - 9535134760 9535134752 9535146645 PB - IntechOpen DB - UniCat KW - Vaccines. KW - Biologicals KW - Life Sciences KW - Immunology and Microbiology KW - Applied Immunology KW - Reverse Vaccinology UR - https://www.unicat.be/uniCat?func=search&query=sysid:31331148 AB - Microbes that elude host's defenses and have developed resistance to the existing antibiotic arsenal continuously invade the human body. Cure for such diseases is inevitable as it may result in high morbidity and mortality, if not properly treated. Vaccination represents the most cost-effective way for disease prevention. Vaccines activate sentinels of the immune system including macrophages and T, B, and dendritic cells to release a battery of effector molecules and cytokines and ward off infection. For long-lasting protection, the memory cells also need to be evoked. This book encompasses biotechnological vaccines in clinical use, cocooning, disease resurgence postvaccination and other vaccine adverse effects, prospects of therapeutic versus prophylactic vaccines, and design of effective vaccines using bioinformatic tools and engineering molecular pattern interactions. ER -