TY - BOOK ID - 2661681 TI - DNA vaccination / genetic vaccination AU - Koprowski, Hilary AU - Weiner, David B. PY - 1998 VL - 226 SN - 3540633928 3642804772 3642804756 PB - Berlin : Springer, DB - UniCat KW - ADN [Vaccins à ] KW - DNA vaccines KW - DNA-vaccins KW - Genetic vaccines KW - Genetica [Immuno] KW - Genetica--Immunologische aspecten KW - Genetics--Immunological aspects KW - Génétique--Aspects immunologiques KW - Immunity--Genetic aspects KW - Immunogenetica KW - Immunogenetics KW - Immunogénétique KW - Immunologie--Aspects génétiques KW - Immunologie--Genetische aspecten KW - Immunology--Genetic aspects KW - Vaccins [DNA-] KW - Vaccins à ADN KW - Vaccines KW - Gentherapie KW - DNA KW - Vaccines. KW - Gentherapie. KW - DNA. KW - Immunology. KW - Virology. KW - Cancer research. KW - Molecular biology. KW - Cancer Research. KW - Molecular Medicine. KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Cancer research KW - Microbiology KW - Immunobiology KW - Life sciences KW - Serology UR - https://www.unicat.be/uniCat?func=search&query=sysid:2661681 AB - Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec­ tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene­ delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop­ ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro­ duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth. ER -