TY - BOOK ID - 2661678 TI - Cyclin dependent kinase (CDK) inhibitors AU - Vogt, P. K. AU - Reed, S. I. PY - 1998 VL - 227 SN - 3540634290 3642719430 3642719414 9783540634294 PB - Berlin ; Milan ; Paris Springer DB - UniCat KW - Cancer--Pathogenesis KW - Carcinogenese KW - Carcinogenesis KW - Carcinogénèse KW - Cell proliferation KW - Cell renewal KW - Cellen--Proliferatie KW - Cellular proliferation KW - Kanker--Ontstaan KW - Oncogenesis KW - Pathogenesis of cancer KW - Proliferation cellulaire KW - Tumorigenesis KW - Cyclin kinase KW - Inhibitors KW - Immunology. KW - Cell biology. KW - Cancer research. KW - Biochemistry. KW - Cell Biology. KW - Cancer Research. KW - Biochemistry, general. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Medical sciences KW - Cancer research KW - Cell biology KW - Cellular biology KW - Cells KW - Immunobiology KW - Life sciences KW - Serology KW - Composition UR - https://www.unicat.be/uniCat?func=search&query=sysid:2661678 AB - More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so. ER -