TY - BOOK ID - 218346 TI - Galactose regulon of yeast : from genetics to systems biology PY - 2008 SN - 1281241865 9786611241865 3540740155 3540740147 3642093302 PB - Berlin : Springer, DB - UniCat KW - Galactose. KW - Yeast fungi KW - Molecular genetics. KW - Yeasts KW - Fungi KW - Basidiomycetes KW - Blastomycetes KW - Endomycetales KW - Glycosides KW - Monosaccharides KW - Microbiology. KW - Microbial genetics. KW - Microbial genomics. KW - Cytology. KW - Biochemistry. KW - Biotechnology. KW - Microbial Genetics and Genomics. KW - Cell Biology. KW - Biochemistry, general. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Medical sciences KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Genomics KW - Microbial genetics KW - Microorganisms KW - Genetics KW - Microbiology KW - Microbial biology KW - Chemical engineering KW - Genetic engineering KW - Composition KW - Cell biology. UR - https://www.unicat.be/uniCat?func=search&query=sysid:218346 AB - The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed. ER -