TY - BOOK ID - 217285 TI - Current perspectives in micrornas (MIRNA). PY - 2008 SN - 1281773832 9786611773830 1402085338 140208532X 9048179033 PB - [New York ; Dordrecht] : Springer, DB - UniCat KW - Gene silencing. KW - Small interfering RNA. KW - piRNA (Piwi-interacting RNA) KW - Piwi-interacting RNA KW - Piwi protein-interacting RNA KW - rasiRNA (Repeat-associated small interfering RNA) KW - Repeat-associated siRNA KW - Repeat-associated small interfering RNA KW - Scan RNA KW - scnRNA (Small scan RNA) KW - Short hairpin RNA KW - Short interfering RNA KW - shRNA (Short hairpin RNA) KW - siRNA (Small interfering RNA) KW - Small hairpin RNA KW - Small scan RNA KW - tasiRNA (Trans-acting small interfering RNA) KW - Trans-acting siRNA KW - Trans-acting small interfering RNA KW - Antisense RNA KW - Gene inactivation KW - Inactivation, Gene KW - Silencing, Gene KW - Genetic regulation KW - Human genetics. KW - Biomedical engineering. KW - Medicine. KW - Neurosciences. KW - Biotechnology. KW - Human Genetics. KW - Biomedical Engineering and Bioengineering. KW - Biomedicine general. KW - Molecular Medicine. KW - Chemical engineering KW - Genetic engineering KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Biophysics KW - Engineering KW - Medicine KW - Neural sciences KW - Neurological sciences KW - Neuroscience KW - Nervous system KW - Genetics KW - Heredity, Human KW - Physical anthropology KW - Health Workforce KW - Molecular biology. KW - Biomedicine, general. KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biomolecules KW - Systems biology UR - https://www.unicat.be/uniCat?func=search&query=sysid:217285 AB - Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions. ER -