TY - BOOK ID - 217233 TI - Oxidants in biology : a question of balance AU - Valacchi, Giuseppe. AU - Davis, Paul A. PY - 2008 SN - 1281492256 9786611492250 1402083998 140208398X 9048178673 PB - [Dordrecht] : Springer, DB - UniCat KW - Oxidation, Physiological. KW - Oxidation. KW - Autoxidation KW - Biological oxidation KW - Oxidation, Biological KW - Physiological oxidation KW - Biochemistry KW - Toxicology. KW - Chemistry. KW - Cytology. KW - Pharmacology/Toxicology. KW - Chemistry/Food Science, general. KW - Cell Biology. KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Physical sciences KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Toxicology KW - Pharmacology. KW - Cell biology. KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:217233 AB - Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review. ER -