TY - BOOK ID - 19493517 TI - P53 in the clinics AU - Hainaut, Pierre. AU - Olivier, Magali. AU - Wiman, Klas G. PY - 2012 SN - 1461436753 9786613935007 1461436761 1283622556 PB - New York : Springer, DB - UniCat KW - p53 antioncogene. KW - p53 protein. KW - Protein p53 KW - Protein TP53 KW - TP53 protein KW - p53 gene KW - p53 suppressor gene KW - Medicine. KW - Cancer research. KW - Pharmacology. KW - Biomedicine. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - DNA-binding proteins KW - Phosphoproteins KW - Tumor suppressor proteins KW - Antioncogenes UR - https://www.unicat.be/uniCat?func=search&query=sysid:19493517 AB - With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of  25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications. ER -