TY - BOOK ID - 19460488 TI - Phosphoinositide 3-kinase in health and disease. AU - Rommel, Christian. AU - Vanhaesebroek, Bart. AU - Vogt, P. K. PY - 2010 SN - 3642136621 9786612971419 1282971417 364213663X PB - New York : Springer, DB - UniCat KW - Phosphoinositides. KW - Cell proliferation. KW - Cell death. KW - Apoptosis. KW - Phosphatidylinositides KW - Phosphatidylinositol phosphates KW - Cell renewal KW - Cellular proliferation KW - Medicine. KW - Cancer research. KW - Human physiology. KW - Molecular biology. KW - Biomedicine. KW - Cancer Research. KW - Human Physiology. KW - Molecular Medicine. KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Human biology KW - Medical sciences KW - Physiology KW - Human body KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Life sciences KW - Pathology KW - Physicians KW - Cell death KW - Cell degeneration KW - Cells KW - Death (Biology) KW - Cell cycle KW - Cell division KW - Cell populations KW - Phospholipids KW - Inositol KW - Growth KW - Oncology. KW - Tumors KW - Health Workforce KW - Cancer. KW - Medicine KW - Biology KW - Cancer Biology. KW - Biomedical Research. KW - Research. KW - Biological research KW - Biomedical research KW - Cancers KW - Carcinoma KW - Malignancy (Cancer) KW - Malignant tumors UR - https://www.unicat.be/uniCat?func=search&query=sysid:19460488 AB - From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here. ER -