TY - BOOK ID - 16241848 TI - Immune Metabolism in Health and Tumor AU - Li, Bin. AU - Pan, Fan. PY - 2017 SN - 9402411704 9402411682 PB - Dordrecht : Springer Netherlands : Imprint: Springer, DB - UniCat KW - Immune system. KW - Cancer. KW - Medicine. KW - Cancer research. KW - Immunology. KW - Medical microbiology. KW - Posttranslational modification. KW - Biomedicine. KW - Posttranslational Modification. KW - Medical Microbiology. KW - Cancer Research. KW - Co-translational modification KW - Cotranslational modification KW - Modification, Post-translational KW - Post-translation protein modification KW - Post-translational protein modification KW - Posttranslation protein modification KW - Posttranslational modification KW - Posttranslational protein modification KW - Genetic translation KW - Proteins KW - Immunobiology KW - Life sciences KW - Serology KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Human biology KW - Medical sciences KW - Pathology KW - Physicians KW - Synthesis KW - Cancers KW - Carcinoma KW - Malignancy (Cancer) KW - Malignant tumors KW - Tumors KW - Immunological system KW - Anatomy KW - Immunology KW - Post-translational modification . KW - Microbiology. KW - Oncology. KW - Microbial biology KW - Biology KW - Microorganisms UR - https://www.unicat.be/uniCat?func=search&query=sysid:16241848 AB - This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics. ER -