TY - BOOK ID - 15993344 TI - Resistance to Molecular Therapies for Hepatocellular Carcinoma PY - 2017 SN - 3319561979 3319561960 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Medicine. KW - Cancer research. KW - Biomedicine. KW - Cancer Research. KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Liver KW - Drug resistance in cancer cells. KW - Cancer KW - Chemotherapy. KW - Antitumor drug resistance KW - Cancer drug resistance KW - Drug resistance in cancer KW - Drug resistance in tumor cells KW - Cancer cells KW - Oncology. KW - Tumors UR - https://www.unicat.be/uniCat?func=search&query=sysid:15993344 AB - This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. ER -