TY - BOOK ID - 1528389 TI - Sodium channels, pain, and analgesia AU - Coward, Kevin AU - Baker, Mark D. PY - 2005 SN - 1281349208 9786611349202 376437411X 3764370629 PB - Basel Birkhäuser DB - UniCat KW - Pain. KW - Sodium channels. KW - Analgesics. KW - Analgetics KW - Anodynes KW - Pain-killing drugs KW - Pain relievers KW - Painkillers KW - Central nervous system depressants KW - Channels, Sodium KW - Ion channels KW - Sodium KW - Aches KW - Emotions KW - Pleasure KW - Senses and sensation KW - Symptoms KW - Analgesia KW - Suffering KW - Physiological transport KW - Neuropathology KW - Pain Medicine. KW - Neurosciences. KW - Toxicology. KW - Cytology. KW - Pharmacology/Toxicology. KW - Cell Biology. KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Neural sciences KW - Neurological sciences KW - Neuroscience KW - Medical sciences KW - Nervous system KW - Toxicology KW - Algiatry KW - Pain medicine. KW - Pharmacology. KW - Cell biology. KW - Drug effects KW - Medical pharmacology KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:1528389 AB - Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme. Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology. ER -