TY - BOOK ID - 146689722 TI - Brain Lipids in Synaptic Function and Neurological Disease : Clues to Innovative Therapeutic Strategies for Brain Disorders AU - Fantini, Jacques. AU - Yahi, Nouara. PY - 2015 PB - Burlington : Elsevier Science, DB - UniCat KW - Brain Chemistry. KW - Brain Diseases. KW - Lipids. KW - Lipid Metabolism. KW - Synaptic Transmission. KW - Membrane Microdomains. UR - https://www.unicat.be/uniCat?func=search&query=sysid:146689722 AB - Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim ER -