TY - BOOK ID - 146280386 TI - The Tight Junction and Its Proteins : More Than Just a Barrier AU - Fromm, Michael AU - Krug, Susanne M. PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - tissue barrier KW - tight junction KW - claudins KW - tricellulin KW - tight junctions KW - organ preservation KW - intestine KW - transplantation KW - ischemia KW - intestinal mucosa KW - lung KW - epithelia KW - interleukin 13 KW - UBE2Z KW - ubiquitin KW - osmolality KW - hydrostatic pressure KW - cancer KW - sensor KW - tricellular tight junctions KW - endometrial cancer KW - epithelial barrier dysfunction KW - Claudin-7 KW - permeability KW - WNK4 KW - epithelial sodium channel (ENaC), collecting duct cells KW - claudin-1 KW - hydrogen peroxide KW - phosphorylation KW - claudin KW - angulin KW - drug development KW - angubindin-1 KW - Clostridium perfringens enterotoxin KW - Clostridium perfringens iota-toxin KW - antibody KW - Mz-ChA-1 cells KW - biliary epithelial cells KW - phosphatidylcholine KW - mucus KW - paracellular transport KW - atopic dermatitis KW - cytokines KW - STAT3 KW - ZO-2 KW - cholestasis KW - gene transcription KW - hypertrophy KW - tumor suppressor KW - NLS KW - NES KW - CaSR KW - RhoA KW - barrier function KW - paracellular permeability KW - antidiuretic hormone KW - Claudin-14 KW - CLDN14 KW - hearing loss KW - vestibular function KW - cochlear implantation KW - Hepatitis C Virus KW - viral entry KW - epidermal barrier KW - reconstructed human epidermis KW - claudin targeting KW - Campylobacter jejuni KW - curcumin KW - apoptosis KW - co-culture KW - mouse colon KW - TNF KW - NFκB KW - lipolysis-stimulated lipoprotein receptor (LSR) KW - epithelial barrier KW - cell–cell contact KW - caspase KW - kidney stones KW - ion reabsorption KW - quercetin KW - brain barriers KW - blood-brain barrier KW - neurovascular unit KW - blood-cerebrospinal fluid barrier KW - arachnoid barrier KW - glia limitans KW - adherens junctions KW - paracellular sodium transport KW - thick ascending limb KW - nephropathy KW - HELIX syndrome KW - hypokalemia KW - hypermagnesemia KW - anhidrosis KW - gland dysfunction KW - aging KW - blood–brain barrier KW - mutations KW - kidney KW - liver KW - skin KW - human KW - mice KW - disease KW - in silico KW - drug discovery KW - membrane proteins KW - protein interactions KW - molecular dynamics KW - antibiotic-associated hemorrhagic colitis KW - Klebsiella oxytoca KW - tight junction assembly KW - monocytes KW - celiac disease KW - claudin-2 KW - epithelium KW - inflammation KW - fibrosis KW - proliferation KW - migration KW - tricellular tight junction KW - paracellular water transport KW - tight epithelium KW - MDCK C7 cells KW - cell growth KW - endothelia KW - adherens junction KW - apical junctional complex KW - AMP-activated protein kinase (AMPK) KW - paracellular barrier KW - protein structure KW - protein domain KW - occludin KW - junctional adhesion molecule KW - zonula occludens KW - MAGUK proteins KW - PDZ domain KW - stem cell KW - chemoresistance KW - retinal pigment epithelium KW - retinopathy KW - barrier formation KW - collecting duct KW - claudin-5 KW - neuropathic pain KW - nerve injury KW - dorsal root ganglion KW - enteropathogenic E. coli (EPEC) KW - tight junctions (TJ) KW - polarity KW - atypical aPKCζ KW - transepithelial electrical resistance (TER) KW - sorting nexin 9 (SNX9) KW - EspF KW - claudin 1 KW - tumor KW - metastasis KW - epithelial to mesenchymal transition KW - cerebral cavernous malformation KW - endothelial barrier KW - Rho KW - ROCK KW - MEKK3 KW - ion transport KW - ion channel KW - super-resolution microscopy KW - structured illumination microscopy KW - stimulated emission depletion KW - single molecule localization microscopy KW - Claudin KW - blood-biliary barrier KW - chronic liver disease KW - hepatocellular carcinoma KW - cholangiocellular carcinoma KW - NISCH syndrome KW - repair KW - NHE2 KW - ClC-2 KW - inflammatory bowel disease KW - mucosal immunology KW - ZO-1 KW - actomyosin KW - aquaporin KW - drinking rate KW - epithelial fluid transport KW - enterocyte KW - osmoregulation KW - paracellular KW - proximal tubule KW - calcium permeability KW - claudin-12 KW - paracellular channels and barriers KW - cell polarity KW - pathogens KW - immune cells KW - environmental sensors KW - tissue barrier KW - tight junction KW - claudins KW - tricellulin KW - tight junctions KW - organ preservation KW - intestine KW - transplantation KW - ischemia KW - intestinal mucosa KW - lung KW - epithelia KW - interleukin 13 KW - UBE2Z KW - ubiquitin KW - osmolality KW - hydrostatic pressure KW - cancer KW - sensor KW - tricellular tight junctions KW - endometrial cancer KW - epithelial barrier dysfunction KW - Claudin-7 KW - permeability KW - WNK4 KW - epithelial sodium channel (ENaC), collecting duct cells KW - claudin-1 KW - hydrogen peroxide KW - phosphorylation KW - claudin KW - angulin KW - drug development KW - angubindin-1 KW - Clostridium perfringens enterotoxin KW - Clostridium perfringens iota-toxin KW - antibody KW - Mz-ChA-1 cells KW - biliary epithelial cells KW - phosphatidylcholine KW - mucus KW - paracellular transport KW - atopic dermatitis KW - cytokines KW - STAT3 KW - ZO-2 KW - cholestasis KW - gene transcription KW - hypertrophy KW - tumor suppressor KW - NLS KW - NES KW - CaSR KW - RhoA KW - barrier function KW - paracellular permeability KW - antidiuretic hormone KW - Claudin-14 KW - CLDN14 KW - hearing loss KW - vestibular function KW - cochlear implantation KW - Hepatitis C Virus KW - viral entry KW - epidermal barrier KW - reconstructed human epidermis KW - claudin targeting KW - Campylobacter jejuni KW - curcumin KW - apoptosis KW - co-culture KW - mouse colon KW - TNF KW - NFκB KW - lipolysis-stimulated lipoprotein receptor (LSR) KW - epithelial barrier KW - cell–cell contact KW - caspase KW - kidney stones KW - ion reabsorption KW - quercetin KW - brain barriers KW - blood-brain barrier KW - neurovascular unit KW - blood-cerebrospinal fluid barrier KW - arachnoid barrier KW - glia limitans KW - adherens junctions KW - paracellular sodium transport KW - thick ascending limb KW - nephropathy KW - HELIX syndrome KW - hypokalemia KW - hypermagnesemia KW - anhidrosis KW - gland dysfunction KW - aging KW - blood–brain barrier KW - mutations KW - kidney KW - liver KW - skin KW - human KW - mice KW - disease KW - in silico KW - drug discovery KW - membrane proteins KW - protein interactions KW - molecular dynamics KW - antibiotic-associated hemorrhagic colitis KW - Klebsiella oxytoca KW - tight junction assembly KW - monocytes KW - celiac disease KW - claudin-2 KW - epithelium KW - inflammation KW - fibrosis KW - proliferation KW - migration KW - tricellular tight junction KW - paracellular water transport KW - tight epithelium KW - MDCK C7 cells KW - cell growth KW - endothelia KW - adherens junction KW - apical junctional complex KW - AMP-activated protein kinase (AMPK) KW - paracellular barrier KW - protein structure KW - protein domain KW - occludin KW - junctional adhesion molecule KW - zonula occludens KW - MAGUK proteins KW - PDZ domain KW - stem cell KW - chemoresistance KW - retinal pigment epithelium KW - retinopathy KW - barrier formation KW - collecting duct KW - claudin-5 KW - neuropathic pain KW - nerve injury KW - dorsal root ganglion KW - enteropathogenic E. coli (EPEC) KW - tight junctions (TJ) KW - polarity KW - atypical aPKCζ KW - transepithelial electrical resistance (TER) KW - sorting nexin 9 (SNX9) KW - EspF KW - claudin 1 KW - tumor KW - metastasis KW - epithelial to mesenchymal transition KW - cerebral cavernous malformation KW - endothelial barrier KW - Rho KW - ROCK KW - MEKK3 KW - ion transport KW - ion channel KW - super-resolution microscopy KW - structured illumination microscopy KW - stimulated emission depletion KW - single molecule localization microscopy KW - Claudin KW - blood-biliary barrier KW - chronic liver disease KW - hepatocellular carcinoma KW - cholangiocellular carcinoma KW - NISCH syndrome KW - repair KW - NHE2 KW - ClC-2 KW - inflammatory bowel disease KW - mucosal immunology KW - ZO-1 KW - actomyosin KW - aquaporin KW - drinking rate KW - epithelial fluid transport KW - enterocyte KW - osmoregulation KW - paracellular KW - proximal tubule KW - calcium permeability KW - claudin-12 KW - paracellular channels and barriers KW - cell polarity KW - pathogens KW - immune cells KW - environmental sensors UR - https://www.unicat.be/uniCat?func=search&query=sysid:146280386 AB - For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer. ER -