TY - BOOK ID - 146280371 TI - Insulin-Like Growth Factors in Development, Cancers and Aging PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - IGF-I KW - IGF-II KW - insulin KW - IGF-IR KW - IRs KW - tyrosine kinase receptor KW - GPCRs KW - hybrids KW - phosphorylation KW - G-proteins KW - β-arrestins KW - functional RTK/GPCR hybrid KW - nuclear translocation KW - IGF-I receptor KW - signaling KW - targeted therapeutics KW - IGF-Trap KW - IGF system KW - IGFBP-3 KW - IGFBP-3R KW - TMEM219 KW - anti-tumor KW - anti-metastatic KW - agonists KW - mAb therapy KW - IGF-1 KW - IGFBP-1 KW - older adults KW - longevity KW - health-span KW - age-related disease KW - cognitive impairment KW - diabetes KW - mitochondria KW - growth hormone KW - insulin-like growth factor-1 KW - aging KW - oxidative stress KW - senescence KW - longitudinal study KW - IGFBP KW - mouse models KW - skeletal muscle KW - MSCs KW - myogenesis KW - glucose regulated protein (GRP) 94 KW - insulin-like growth factor KW - obligate chaperone KW - hypertrophy KW - atrophy KW - cachexia KW - muscle regeneration KW - autophagy KW - IGF-1R KW - insulin receptor KW - IR-A KW - structural studies KW - receptor activation KW - IGF-I KW - IGF-II KW - insulin KW - IGF-IR KW - IRs KW - tyrosine kinase receptor KW - GPCRs KW - hybrids KW - phosphorylation KW - G-proteins KW - β-arrestins KW - functional RTK/GPCR hybrid KW - nuclear translocation KW - IGF-I receptor KW - signaling KW - targeted therapeutics KW - IGF-Trap KW - IGF system KW - IGFBP-3 KW - IGFBP-3R KW - TMEM219 KW - anti-tumor KW - anti-metastatic KW - agonists KW - mAb therapy KW - IGF-1 KW - IGFBP-1 KW - older adults KW - longevity KW - health-span KW - age-related disease KW - cognitive impairment KW - diabetes KW - mitochondria KW - growth hormone KW - insulin-like growth factor-1 KW - aging KW - oxidative stress KW - senescence KW - longitudinal study KW - IGFBP KW - mouse models KW - skeletal muscle KW - MSCs KW - myogenesis KW - glucose regulated protein (GRP) 94 KW - insulin-like growth factor KW - obligate chaperone KW - hypertrophy KW - atrophy KW - cachexia KW - muscle regeneration KW - autophagy KW - IGF-1R KW - insulin receptor KW - IR-A KW - structural studies KW - receptor activation UR - https://www.unicat.be/uniCat?func=search&query=sysid:146280371 AB - This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners. ER -