TY - BOOK ID - 146249710 TI - Predictive Markers of Treatment Resistance in Head and Neck Squamous Cell Carcinoma PY - 2012 SN - 9789175199689 PB - Linkopings Universitet DB - UniCat KW - Drug resistance in cancer cells. KW - Biochemical markers. KW - Drug resistance in cancer cells KW - Biochemical markers UR - https://www.unicat.be/uniCat?func=search&query=sysid:146249710 AB - This dissertation explores predictive markers of treatment resistance in head and neck squamous cell carcinoma. The research by Fredrik Jerhammar aims to identify novel biomarkers that can predict responses to treatments like radiation, cisplatin, and cetuximab. By analyzing protein expressions and gene mutations in various cell lines, the study proposes combinations of markers, such as EGFR and survivin, that correlate with intrinsic resistance. The findings suggest that certain genetic profiles, including MMP-7 and FN1 expression, may indicate higher resistance to specific therapies. The goal is to enhance personalized medicine by tailoring treatment plans based on these markers, ultimately improving patient outcomes. The intended audience includes medical researchers and clinicians in oncology and personalized medicine fields. ER -