TY - BOOK ID - 146184020 TI - Molecular Psychiatry AU - Rein, Theo AU - Fries, Gabriel R. PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - Mental health services KW - cardiovascular disease KW - cell adhesion molecules KW - immunology KW - inflammation KW - nervous system KW - schizophrenia KW - bipolar disorder KW - major depressive disorder KW - DNA methylation KW - response variability KW - antipsychotics KW - drug design KW - multi-target drugs KW - polypharmacology KW - multi-task learning KW - machine learning KW - biomarker discovery KW - psychiatry KW - serotonin KW - 5-HT 4 receptor KW - 5-HT4R KW - depression KW - mood disorder KW - expression KW - Alzheimer's disease KW - cognition KW - Parkinson's disease KW - forced swimming KW - Roman rat lines KW - stress KW - hippocampus KW - BDNF KW - trkB KW - PSA-NCAM KW - western blot KW - immunohistochemistry KW - general cognitive function KW - intelligence KW - GWAS KW - genetic correlation KW - childhood-onset schizophrenia (COS) KW - induced pluripotent stem cell (iPSC) KW - copy number variation (CNV) KW - early neurodevelopment KW - neuronal differentiation KW - synapse KW - dendritic arborization KW - miRNAs KW - stress physiology KW - cytoskeleton KW - actin dynamics KW - DRR1 KW - TU3A KW - FAM107A KW - acid sphingomyelinase KW - alcohol dependence KW - liver enzymes KW - sphingolipid metabolism KW - withdrawal KW - Hsp90 KW - GR KW - stress response KW - steroid hormones KW - molecular chaperones KW - psychiatric disease KW - circadian rhythms KW - FKBP51 KW - FKBP52 KW - CyP40 KW - PP5 KW - DISC1 KW - neurodevelopment KW - CRMP-2 KW - proteomics KW - antidepressant treatment KW - HPA axis KW - gene expression KW - FKBP5 KW - sleep KW - sleep EEG KW - biomarkers KW - antidepressants KW - cordance KW - gender KW - sex difference KW - antidepressant KW - rapid-acting KW - Ketamine KW - endocrinology KW - (2R,6R)-Hydroxynorketamine KW - electroconvulsive therapy KW - basic-helix-loop-helix KW - brain KW - coactivator KW - glucocorticoids KW - mineralocorticoid receptor knockout KW - transcription biology KW - dopaminergic gene polymorphisms KW - affective temperament KW - obesity KW - alpha-synuclein KW - SNCA KW - major depression KW - Hamilton Scale of Depression KW - chemokines KW - neuroinflammation KW - social defeat KW - Immune response KW - T cells KW - susceptibility KW - resilience KW - Treg cells KW - Th17 cells KW - behavior KW - PPARĪ³ KW - cardiovascular disease KW - cell adhesion molecules KW - immunology KW - inflammation KW - nervous system KW - schizophrenia KW - bipolar disorder KW - major depressive disorder KW - DNA methylation KW - response variability KW - antipsychotics KW - drug design KW - multi-target drugs KW - polypharmacology KW - multi-task learning KW - machine learning KW - biomarker discovery KW - psychiatry KW - serotonin KW - 5-HT 4 receptor KW - 5-HT4R KW - depression KW - mood disorder KW - expression KW - Alzheimer's disease KW - cognition KW - Parkinson's disease KW - forced swimming KW - Roman rat lines KW - stress KW - hippocampus KW - BDNF KW - trkB KW - PSA-NCAM KW - western blot KW - immunohistochemistry KW - general cognitive function KW - intelligence KW - GWAS KW - genetic correlation KW - childhood-onset schizophrenia (COS) KW - induced pluripotent stem cell (iPSC) KW - copy number variation (CNV) KW - early neurodevelopment KW - neuronal differentiation KW - synapse KW - dendritic arborization KW - miRNAs KW - stress physiology KW - cytoskeleton KW - actin dynamics KW - DRR1 KW - TU3A KW - FAM107A KW - acid sphingomyelinase KW - alcohol dependence KW - liver enzymes KW - sphingolipid metabolism KW - withdrawal KW - Hsp90 KW - GR KW - stress response KW - steroid hormones KW - molecular chaperones KW - psychiatric disease KW - circadian rhythms KW - FKBP51 KW - FKBP52 KW - CyP40 KW - PP5 KW - DISC1 KW - neurodevelopment KW - CRMP-2 KW - proteomics KW - antidepressant treatment KW - HPA axis KW - gene expression KW - FKBP5 KW - sleep KW - sleep EEG KW - biomarkers KW - antidepressants KW - cordance KW - gender KW - sex difference KW - antidepressant KW - rapid-acting KW - Ketamine KW - endocrinology KW - (2R,6R)-Hydroxynorketamine KW - electroconvulsive therapy KW - basic-helix-loop-helix KW - brain KW - coactivator KW - glucocorticoids KW - mineralocorticoid receptor knockout KW - transcription biology KW - dopaminergic gene polymorphisms KW - affective temperament KW - obesity KW - alpha-synuclein KW - SNCA KW - major depression KW - Hamilton Scale of Depression KW - chemokines KW - neuroinflammation KW - social defeat KW - Immune response KW - T cells KW - susceptibility KW - resilience KW - Treg cells KW - Th17 cells KW - behavior KW - PPARĪ³ UR - https://www.unicat.be/uniCat?func=search&query=sysid:146184020 AB - The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders. ER -