TY - BOOK ID - 146184011 TI - Marine Natural Products as Anticancer Agents AU - Alves, Celso AU - Diederich, Marc PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - alga KW - marine-derived fungus KW - Penicillium chrysogenum KW - polyketide KW - hydroxyphenylacetic acid KW - cytotoxicity KW - flaccidoxide-13-acetate KW - hepatocellular carcinoma KW - invasion KW - migration KW - epithelial-mesenchymal transition KW - prostate cancer KW - astaxanthin KW - STAT3 KW - proliferation KW - colony formation KW - apoptosis KW - Sarcophyton digitatum KW - biscembranoid-type metabolites KW - inflammatory factor production KW - LPS-stimulated murine macrophage KW - Ehlich's tumor KW - P. purpurogenum KW - antitumor KW - meroterpenoids KW - inflammation KW - T47D KW - BT20 KW - pontin KW - mutp53 KW - cancer stem cells KW - Oct4 KW - Nanog KW - siRNA KW - secondary metabolites KW - epigenome KW - epigenetic signaling KW - bioactive compounds KW - cancer therapy KW - marine species KW - environment KW - total synthesis KW - natural product KW - nannocystin KW - anti-cancer KW - gram-scale KW - aplysinopsin analogs KW - indole alkaloids KW - marine source KW - chronic myeloid leukemia KW - BH3 mimetics UR - https://www.unicat.be/uniCat?func=search&query=sysid:146184011 AB - Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment. ER -