TY - BOOK ID - 146161864 TI - PPARs as Key Mediators of Metabolic and Inflammatory Regulation AU - Vázquez-Carrera, Manuel AU - Wahli, Walter PY - 2022 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - Biochemistry KW - nuclear receptor KW - gene transcription KW - inflammation KW - molecular docking KW - PPARβ/δ KW - lung KW - pulmonary artery KW - GW0742 KW - GSK3787 KW - docking KW - lipopolysaccharide (LPS) KW - PPARγ ligand KW - coumarin KW - fluorescent ligand KW - screening KW - crystal structure KW - PPAR KW - atopic dermatitis KW - psoriasis KW - metabolic reprograming KW - glucose KW - fatty acids KW - mycobacteria KW - M. tuberculosis KW - M. leprae KW - PPARs KW - lipid droplets KW - metabolic alterations KW - hepatic damage KW - nuclear factors KW - pharmacological targets KW - AMPK KW - GDF15 KW - insulin resistance KW - type 2 diabetes mellitus KW - peroxisome proliferator-activated receptor gamma (PPARγ) KW - real-time PCR KW - ELISA KW - immunohistochemistry KW - signaling pathway KW - PPAR gamma KW - brain KW - neural stem cells KW - infection KW - neuroinflammation KW - HIV KW - Zika KW - cytomegalovirus KW - neurogenesis KW - microglia KW - liver damage KW - toll-like receptor 4 KW - P2Y2 receptor KW - metabolic syndrome KW - resveratrol KW - quercetin KW - PPARα KW - peroxisome KW - β-oxidation KW - PPRE KW - ligand KW - coregulator KW - micronutrients KW - PPARα knockout KW - adipose tissue KW - browning KW - lipid metabolism KW - depression KW - PPARg KW - neuropathology KW - corticotropin releasing hormone KW - norepinephrine KW - subgenual prefrontal cortex KW - amygdala KW - nucleus accumbens KW - common carotid artery occlusion KW - electroretinography KW - fibroblast growth factor 21 KW - pemafibrate KW - peroxisome proliferator-activated receptor alpha KW - retinal ischemia KW - skeletal muscle KW - substrate metabolism KW - nonalcoholic fatty liver disease (NAFLD) KW - sex dimorphism KW - lipidomics KW - hepatic sex-biased gene expression KW - PPARγ KW - pulmonary arterial hypertension KW - TGFβ KW - vascular injury KW - proliferation KW - kidney fibrosis KW - pattern-recognition receptors KW - phagocytosis KW - nitric oxide synthase KW - fenofibrate KW - oleoylethanolamide KW - palmitoylethanolamide KW - cancer KW - immunity KW - obesity KW - diabetes KW - miRNA KW - DNA methylation KW - histone modification KW - peroxisome-proliferator-activated receptor KW - fatty acid oxidation KW - doping control KW - regulatory T cells KW - exercise KW - nuclear receptors KW - nutrigenomics KW - energy homeostasis KW - dairy animals KW - non-alcoholic fatty liver disease (NAFLD) KW - non-alcoholic steatohepatitis (NASH) KW - peroxisome proliferator-activated receptors (PPAR) KW - bezafibrate KW - fenofibric acid KW - peroxisome proliferator-activated receptor KW - dual/pan agonist KW - X-ray crystallography KW - nuclear receptor KW - gene transcription KW - inflammation KW - molecular docking KW - PPARβ/δ KW - lung KW - pulmonary artery KW - GW0742 KW - GSK3787 KW - docking KW - lipopolysaccharide (LPS) KW - PPARγ ligand KW - coumarin KW - fluorescent ligand KW - screening KW - crystal structure KW - PPAR KW - atopic dermatitis KW - psoriasis KW - metabolic reprograming KW - glucose KW - fatty acids KW - mycobacteria KW - M. tuberculosis KW - M. leprae KW - PPARs KW - lipid droplets KW - metabolic alterations KW - hepatic damage KW - nuclear factors KW - pharmacological targets KW - AMPK KW - GDF15 KW - insulin resistance KW - type 2 diabetes mellitus KW - peroxisome proliferator-activated receptor gamma (PPARγ) KW - real-time PCR KW - ELISA KW - immunohistochemistry KW - signaling pathway KW - PPAR gamma KW - brain KW - neural stem cells KW - infection KW - neuroinflammation KW - HIV KW - Zika KW - cytomegalovirus KW - neurogenesis KW - microglia KW - liver damage KW - toll-like receptor 4 KW - P2Y2 receptor KW - metabolic syndrome KW - resveratrol KW - quercetin KW - PPARα KW - peroxisome KW - β-oxidation KW - PPRE KW - ligand KW - coregulator KW - micronutrients KW - PPARα knockout KW - adipose tissue KW - browning KW - lipid metabolism KW - depression KW - PPARg KW - neuropathology KW - corticotropin releasing hormone KW - norepinephrine KW - subgenual prefrontal cortex KW - amygdala KW - nucleus accumbens KW - common carotid artery occlusion KW - electroretinography KW - fibroblast growth factor 21 KW - pemafibrate KW - peroxisome proliferator-activated receptor alpha KW - retinal ischemia KW - skeletal muscle KW - substrate metabolism KW - nonalcoholic fatty liver disease (NAFLD) KW - sex dimorphism KW - lipidomics KW - hepatic sex-biased gene expression KW - PPARγ KW - pulmonary arterial hypertension KW - TGFβ KW - vascular injury KW - proliferation KW - kidney fibrosis KW - pattern-recognition receptors KW - phagocytosis KW - nitric oxide synthase KW - fenofibrate KW - oleoylethanolamide KW - palmitoylethanolamide KW - cancer KW - immunity KW - obesity KW - diabetes KW - miRNA KW - DNA methylation KW - histone modification KW - peroxisome-proliferator-activated receptor KW - fatty acid oxidation KW - doping control KW - regulatory T cells KW - exercise KW - nuclear receptors KW - nutrigenomics KW - energy homeostasis KW - dairy animals KW - non-alcoholic fatty liver disease (NAFLD) KW - non-alcoholic steatohepatitis (NASH) KW - peroxisome proliferator-activated receptors (PPAR) KW - bezafibrate KW - fenofibric acid KW - peroxisome proliferator-activated receptor KW - dual/pan agonist KW - X-ray crystallography UR - https://www.unicat.be/uniCat?func=search&query=sysid:146161864 AB - Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, α, β/δ, and γ, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species. ER -