TY - BOOK ID - 146137232 TI - Brain Networks and Dynamics in Narcolepsy PY - 2019 SN - 9789176851814 PB - Linkopings Universitet DB - UniCat KW - Narcolepsy. KW - Brain mapping. UR - https://www.unicat.be/uniCat?func=search&query=sysid:146137232 AB - This dissertation explores the neurobiological mechanisms and aetiology of narcolepsy, focusing on the dynamics of brain networks in adolescents with Type 1 narcolepsy. Utilizing various neuroimaging techniques, the research identifies structural and functional deviations in brain regions, particularly related to Orexin-A loss, which affects cognition and metabolism. The study finds correlations between brain anomalies and cognitive performance, highlighting potential therapeutic targets. Additionally, it examines the relationship between narcolepsy and weight gain, suggesting that changes in Orexin may influence adipose tissue distribution rather than volume. The work aims to advance understanding of narcolepsy's impact on brain function and its broader implications for health. ER -