TY - BOOK ID - 146090533 TI - Advances and Novel Treatment Options in Metastatic Melanoma AU - Facchiano, Antonio AU - Del Bufalo, Donatella AU - Carè€, Alessandra PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - melanoma KW - invasion KW - WNT5A KW - MARCKS KW - phosphorylation KW - MANS peptide KW - nanoparticles KW - cell therapy KW - tumor microenvironment KW - sex/gender KW - sex-hormones KW - immunity KW - microRNAs KW - immunotherapy KW - BRAF-mutant melanoma KW - BRAF inhibitor KW - mechanism of action KW - targeted therapy KW - tumour microenvironment KW - plasmacytoid dendritic cells KW - lactate dehydrogenase KW - TLR KW - interferon KW - CXCL10 KW - TPC2 KW - HIPPO KW - SOCE KW - metastasis KW - essential oils KW - angiogenesis KW - apoptosis KW - uveal melanoma (UM) KW - metastatic uveal melanoma (mUM) KW - prognostication KW - adjuvant therapy KW - metastatic therapy KW - metastatic dormancy KW - liver-directed-therapies KW - targeted-therapy KW - combined therapy KW - protein tyrosine phosphatase KW - PTPs inhibitors KW - melanoma immune infiltrate KW - BRAF inhibitors KW - microenvironment KW - resistance KW - therapy KW - therapeutic resistance KW - exosomes KW - extracellular vesicles KW - diagnosis KW - prognosis KW - ctDNA KW - liquid biopsy KW - prediction KW - patient stratification KW - BRAF KW - arthralgia KW - rheumatoid arthritis KW - carbonic anhydrase KW - hedgehog KW - cyclopamine KW - small molecules KW - acetazolamide KW - motility KW - metalloproteinases KW - FAK KW - cancer KW - mucosal melanoma KW - nivolumab KW - pembrolizumab KW - ipilimumab KW - radiotherapy KW - cholinergic system KW - acetylcholine KW - muscarinic receptors KW - nicotinic receptors KW - melanoma metastasis KW - ShcD adaptor protein KW - amoeboid motility KW - Rac1 KW - DOCK4 KW - melanoma PDX KW - target therapy KW - cancer stem cells KW - slow cycling phenotype KW - drug resistance KW - OXPHOS KW - lipid metabolism KW - cancer associated fibroblast KW - melanomagenesis KW - biomarkers KW - checkpoint inhibitor KW - PD-1 KW - melanoma markers KW - cytokines KW - machine learning KW - Support Vector Machine KW - principal component analysis KW - BCL2L10 KW - STAT3 KW - cytotoxicity KW - survival KW - ABT-737 KW - Bcl-2 family KW - ML258 KW - HuR KW - MITF KW - metastases KW - siRNA KW - melanoma KW - invasion KW - WNT5A KW - MARCKS KW - phosphorylation KW - MANS peptide KW - nanoparticles KW - cell therapy KW - tumor microenvironment KW - sex/gender KW - sex-hormones KW - immunity KW - microRNAs KW - immunotherapy KW - BRAF-mutant melanoma KW - BRAF inhibitor KW - mechanism of action KW - targeted therapy KW - tumour microenvironment KW - plasmacytoid dendritic cells KW - lactate dehydrogenase KW - TLR KW - interferon KW - CXCL10 KW - TPC2 KW - HIPPO KW - SOCE KW - metastasis KW - essential oils KW - angiogenesis KW - apoptosis KW - uveal melanoma (UM) KW - metastatic uveal melanoma (mUM) KW - prognostication KW - adjuvant therapy KW - metastatic therapy KW - metastatic dormancy KW - liver-directed-therapies KW - targeted-therapy KW - combined therapy KW - protein tyrosine phosphatase KW - PTPs inhibitors KW - melanoma immune infiltrate KW - BRAF inhibitors KW - microenvironment KW - resistance KW - therapy KW - therapeutic resistance KW - exosomes KW - extracellular vesicles KW - diagnosis KW - prognosis KW - ctDNA KW - liquid biopsy KW - prediction KW - patient stratification KW - BRAF KW - arthralgia KW - rheumatoid arthritis KW - carbonic anhydrase KW - hedgehog KW - cyclopamine KW - small molecules KW - acetazolamide KW - motility KW - metalloproteinases KW - FAK KW - cancer KW - mucosal melanoma KW - nivolumab KW - pembrolizumab KW - ipilimumab KW - radiotherapy KW - cholinergic system KW - acetylcholine KW - muscarinic receptors KW - nicotinic receptors KW - melanoma metastasis KW - ShcD adaptor protein KW - amoeboid motility KW - Rac1 KW - DOCK4 KW - melanoma PDX KW - target therapy KW - cancer stem cells KW - slow cycling phenotype KW - drug resistance KW - OXPHOS KW - lipid metabolism KW - cancer associated fibroblast KW - melanomagenesis KW - biomarkers KW - checkpoint inhibitor KW - PD-1 KW - melanoma markers KW - cytokines KW - machine learning KW - Support Vector Machine KW - principal component analysis KW - BCL2L10 KW - STAT3 KW - cytotoxicity KW - survival KW - ABT-737 KW - Bcl-2 family KW - ML258 KW - HuR KW - MITF KW - metastases KW - siRNA UR - https://www.unicat.be/uniCat?func=search&query=sysid:146090533 AB - The book presents several studies reporting advances on melanoma pathogenesis, diagnosis and therapy. It represents a milestone on the state of the art, updated at 2021, and also presents the current knowledge on the future developments in melanoma field. ER -