TY - BOOK ID - 146026589 TI - Protein-Ligand Interactions: Target Identification and Drug Discovery PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Chemistry KW - serum half-life extension KW - fatty acid conjugation KW - FcRn-mediated recycling KW - serum albumin KW - translocator protein (TSPO) KW - CoCl2 KW - mitochondrial membrane potential KW - reactive oxygen species (ROS) KW - cell viability KW - cell death KW - lung cancer cell line KW - acetylcholinesterase KW - amyloid beta aggregation KW - neuroprotection KW - molecular docking KW - multi-target drug KW - structure–activity relationship KW - brassicasterol KW - phytosterols KW - HSV KW - Mycobacterium tuberculosis KW - HSV-1 DNA polymerase KW - HSV-1 TK KW - human CDK2 KW - ACE KW - UDP-galactopyranose mutase KW - heat shock protein 70 KW - Hsp70 KW - piperine KW - fluorescence spectroscopy KW - molecular dynamics KW - molecular biophysics KW - GADD45β KW - MKK7 KW - multiple myeloma KW - protein-ligand interaction KW - STD-NMR KW - sigma receptors KW - sigma ligands KW - cancer KW - SIGMAR1 KW - PGRMC1 KW - TMEM97 KW - NCI60 COMPARE analysis KW - membrane KW - lipid-protein interaction KW - lipid signalling KW - kinase regulation KW - phosphatidylinositols KW - molecular docking simulation KW - target identification KW - small-molecule derivatives of salicylanilide KW - drug discovery KW - drug development KW - thyroid diseases KW - endocrine disruptor compound KW - human umbilical artery KW - vascular homeostasis UR - https://www.unicat.be/uniCat?func=search&query=sysid:146026589 AB - Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. ER -