TY - BOOK ID - 145999426 TI - Staphylococcal Infections (Host and Pathogenic Factors) PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - biofilm KW - MRSA KW - silver ion KW - silver sulfadiazine KW - wound infections KW - Staphylococcus aureus KW - methicillin resistance KW - human infection KW - CC130 KW - biomaterials KW - medical devices KW - HL-60 cells KW - PMNs KW - endotracheal tube KW - titanium KW - implantable devices KW - nosocomial diseases KW - Staphylococcus lugdunensis KW - sortase A KW - surface proteins KW - LPXTG KW - small colony variants KW - influenza virus KW - super-infection KW - pro-inflammatory response KW - rural Ghana KW - molecular epidemiology KW - chronic wounds KW - invasive disease KW - surgery-associated infection KW - sepsis KW - SA4Ag vaccine KW - conjugated polysaccharide KW - ClfA KW - MntC KW - protection KW - animal models KW - phase variation KW - Staphylococcus epidermidis KW - microbiota KW - multidrug resistance KW - genome sequencing KW - phylogenetic analyses KW - arthroplasty surgery KW - methicillin-resistant Staphylococcus aureus (MRSA) KW - community-associated MRSA (CA-MRSA) KW - CA-MRSA strain USA300 KW - murine skin infection model KW - dermatopathology KW - dermonecrosis KW - neutrophil KW - host antibacterial response KW - cytokine KW - chemokine KW - physiology KW - metabolism KW - carbon catabolite repression KW - CcpA KW - HPr KW - colonization KW - mouse KW - JSNZ KW - aurintricarboxylic acid KW - ATA KW - adhesion inhibitor KW - mupirocin KW - nose KW - superantigen KW - mastitis KW - food intoxication KW - regulation KW - sec variants KW - CM lipids KW - daptomycin resistance KW - resensitization KW - biofilm KW - MRSA KW - silver ion KW - silver sulfadiazine KW - wound infections KW - Staphylococcus aureus KW - methicillin resistance KW - human infection KW - CC130 KW - biomaterials KW - medical devices KW - HL-60 cells KW - PMNs KW - endotracheal tube KW - titanium KW - implantable devices KW - nosocomial diseases KW - Staphylococcus lugdunensis KW - sortase A KW - surface proteins KW - LPXTG KW - small colony variants KW - influenza virus KW - super-infection KW - pro-inflammatory response KW - rural Ghana KW - molecular epidemiology KW - chronic wounds KW - invasive disease KW - surgery-associated infection KW - sepsis KW - SA4Ag vaccine KW - conjugated polysaccharide KW - ClfA KW - MntC KW - protection KW - animal models KW - phase variation KW - Staphylococcus epidermidis KW - microbiota KW - multidrug resistance KW - genome sequencing KW - phylogenetic analyses KW - arthroplasty surgery KW - methicillin-resistant Staphylococcus aureus (MRSA) KW - community-associated MRSA (CA-MRSA) KW - CA-MRSA strain USA300 KW - murine skin infection model KW - dermatopathology KW - dermonecrosis KW - neutrophil KW - host antibacterial response KW - cytokine KW - chemokine KW - physiology KW - metabolism KW - carbon catabolite repression KW - CcpA KW - HPr KW - colonization KW - mouse KW - JSNZ KW - aurintricarboxylic acid KW - ATA KW - adhesion inhibitor KW - mupirocin KW - nose KW - superantigen KW - mastitis KW - food intoxication KW - regulation KW - sec variants KW - CM lipids KW - daptomycin resistance KW - resensitization UR - https://www.unicat.be/uniCat?func=search&query=sysid:145999426 AB - Although 30% of the healthy human population is colonized with various Staphylococcus species, some staphylococcal strains, referred to as opportunistic pathogens, can cause minor to life-threatening diseases. The pathogenicity of these bacteria depends on their virulence factors and the robustness of the regulatory networks expressing these virulence factors. Virulence factors of pathogenic Staphylococcus spp. consist of numerous toxins, enterotoxins (some of which act as superantigens), enzymes, and proteins (cytoplasmic, extracellular, and surface) that are regulated by two-component (TC) and quorum-sensing (QS) regulatory networks. To enter this niche, some other Staphylococcus species, such as Staphylococcus simulans, produce a potent endopeptidase called lysostaphin, which can inhibit the growth of pathogenic S. aureus. Some other Staphylococcus species produce autolysins and cationic peptides to win the intra- and inter-species competition. The outcome of this microbial invasion depends not only on pathogenic factors but also on the host’s internal and external defense mechanisms, including a healthy skin microbiome. A healthy skin microbiome population can prevent colonization by other major pathogens. As normal host microflora, these commensals establish a complex relationship with the host as well as the surrounding microbial communities. This Special Issue of Microorganisms is focused on studies and recent advancements in our understanding of staphylococcal virulence mechanisms that enable Staphylococcus spp. either to successfully establish themselves as a colonizer or to overcome the host’s defense system to cause infection along with our effort to make an anti-staphylococcal vaccine. ER -