TY - BOOK ID - 145951471 TI - Zika Virus and Host Interactions AU - Hobman, Tom AU - Kumar, Anil AU - Limonta, Daniel PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - Zika virus KW - peroxisomes KW - innate immune response KW - interferon KW - astrocytes KW - fetal brain KW - zika virus KW - flaviviruses KW - T cells KW - host-pathogen interactions KW - flavivirus KW - tight junctions KW - claudins KW - ZO-1 KW - blood-placental barrier KW - placenta KW - apoptosis KW - viral replication KW - Bcl-2 protein family KW - ZIKV KW - virus host interactions KW - pathogenesis KW - MR766 KW - guinea pig KW - subcutaneous KW - vaginal KW - sexual transmission KW - virus transmission KW - envelope protein KW - glycosylation KW - fusion loop KW - viral fusion KW - cell entry KW - NS5 protein KW - nuclear localization KW - inflammation KW - innate immunity KW - extracellular vesicles KW - cellular communication KW - C6/36 cells KW - human monocytes KW - endothelial vascular cells KW - protein–protein interaction KW - non-structural viral proteins KW - network KW - JAK/STAT KW - cytokine KW - West Nile virus KW - HSP90 KW - NS5 KW - virus–host interactions KW - anti-viral signaling KW - immune response KW - inflammatory mediator KW - Sertoli cells KW - Leydig cells KW - ZIKA virus KW - arboviruses KW - infertility KW - IFN KW - RIG-I KW - MDA5 KW - IFNAR1 KW - zika KW - host KW - cell death KW - peroxisome KW - mosquito KW - tight junction KW - Zika virus KW - peroxisomes KW - innate immune response KW - interferon KW - astrocytes KW - fetal brain KW - zika virus KW - flaviviruses KW - T cells KW - host-pathogen interactions KW - flavivirus KW - tight junctions KW - claudins KW - ZO-1 KW - blood-placental barrier KW - placenta KW - apoptosis KW - viral replication KW - Bcl-2 protein family KW - ZIKV KW - virus host interactions KW - pathogenesis KW - MR766 KW - guinea pig KW - subcutaneous KW - vaginal KW - sexual transmission KW - virus transmission KW - envelope protein KW - glycosylation KW - fusion loop KW - viral fusion KW - cell entry KW - NS5 protein KW - nuclear localization KW - inflammation KW - innate immunity KW - extracellular vesicles KW - cellular communication KW - C6/36 cells KW - human monocytes KW - endothelial vascular cells KW - protein–protein interaction KW - non-structural viral proteins KW - network KW - JAK/STAT KW - cytokine KW - West Nile virus KW - HSP90 KW - NS5 KW - virus–host interactions KW - anti-viral signaling KW - immune response KW - inflammatory mediator KW - Sertoli cells KW - Leydig cells KW - ZIKA virus KW - arboviruses KW - infertility KW - IFN KW - RIG-I KW - MDA5 KW - IFNAR1 KW - zika KW - host KW - cell death KW - peroxisome KW - mosquito KW - tight junction UR - https://www.unicat.be/uniCat?func=search&query=sysid:145951471 AB - Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design. ER -