TY - BOOK ID - 145889608 TI - Organs-On-chips for the Pharmaceutical Development Process : Design Perspectives and Implementations PY - 2018 SN - 9789176853597 PB - Linkopings Universitet DB - UniCat KW - Biochips. KW - Microfluidics. KW - Biochips KW - Microfluidics UR - https://www.unicat.be/uniCat?func=search&query=sysid:145889608 AB - This dissertation explores the development and design of organs-on-chips, dynamic cell culture devices that mimic organ function in vitro. These devices are intended to improve the assessment of drug toxicity and efficacy during the early stages of the drug development process, aiming to better predict clinical trial outcomes. The work discusses the complexity of cell environments and highlights how three-dimensional cell cultures, mechanical stimuli, and other advanced methodologies can enhance cell functionality compared to traditional two-dimensional static models. The research includes examples of 3D spheroids, hydrogels, and electroosmotic pumps, contributing to the field with a conceptual design process for creating new organ-on-chip prototypes. The intended audience includes researchers and professionals in biotechnology, biomedical engineering, and related fields. ER -