TY - BOOK ID - 145847431 TI - The Alveolar Epithelium : Mechanisms of Injury and Repair AU - Kasper, Michael AU - Mühlfeld, Christian PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - JAM-A KW - P2X7 receptor KW - mouse lung KW - alveolar epithelium KW - bleomycin-induced lung injury KW - GSK-3β KW - dietary sugar KW - hyperglycemia KW - lung mechanics KW - alveolar septal composition KW - physical activity KW - extracellular matrix remodeling KW - high-altitude pulmonary edema KW - acute mountain sickness KW - oxygen diffusion limitation KW - surfactant protein B KW - atelectrauma KW - alveolar fluid KW - acinar micromechanics KW - acute lung injury KW - autophagy KW - lysosome KW - lysosomal membrane permeability KW - mitochondria KW - pneumocyte KW - microRNA-21 KW - alveolar micromechanics KW - structural remodeling KW - inflammatory signaling KW - lung KW - alveolus KW - type 1 alveolar epithelial cell KW - type 2 alveolar epithelial cell KW - focused ion beam scanning electron microscopy KW - 3D reconstruction KW - carbon dioxide KW - hypercapnia KW - Na,K-ATPase KW - endoplasmic reticulum KW - sodium transport KW - protein oxidation KW - alveolar epithelial cells KW - pulmonary fibrosis KW - epithelial cell dysfunction KW - stem cell exhaustion KW - pneumonia KW - necrotizing KW - regeneration KW - model KW - bovine KW - chlamydia KW - alveoli KW - air-blood barrier KW - epithelium KW - air-liquid interface KW - alveolar lining layer KW - glycocalyx KW - surfactant KW - lung injury KW - lung regeneration KW - JAM-A KW - P2X7 receptor KW - mouse lung KW - alveolar epithelium KW - bleomycin-induced lung injury KW - GSK-3β KW - dietary sugar KW - hyperglycemia KW - lung mechanics KW - alveolar septal composition KW - physical activity KW - extracellular matrix remodeling KW - high-altitude pulmonary edema KW - acute mountain sickness KW - oxygen diffusion limitation KW - surfactant protein B KW - atelectrauma KW - alveolar fluid KW - acinar micromechanics KW - acute lung injury KW - autophagy KW - lysosome KW - lysosomal membrane permeability KW - mitochondria KW - pneumocyte KW - microRNA-21 KW - alveolar micromechanics KW - structural remodeling KW - inflammatory signaling KW - lung KW - alveolus KW - type 1 alveolar epithelial cell KW - type 2 alveolar epithelial cell KW - focused ion beam scanning electron microscopy KW - 3D reconstruction KW - carbon dioxide KW - hypercapnia KW - Na,K-ATPase KW - endoplasmic reticulum KW - sodium transport KW - protein oxidation KW - alveolar epithelial cells KW - pulmonary fibrosis KW - epithelial cell dysfunction KW - stem cell exhaustion KW - pneumonia KW - necrotizing KW - regeneration KW - model KW - bovine KW - chlamydia KW - alveoli KW - air-blood barrier KW - epithelium KW - air-liquid interface KW - alveolar lining layer KW - glycocalyx KW - surfactant KW - lung injury KW - lung regeneration UR - https://www.unicat.be/uniCat?func=search&query=sysid:145847431 AB - Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology. ER -