TY - BOOK ID - 145803771 TI - Coumarin and Its Derivatives PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - coumarin KW - hydroxyl-modified coumarin KW - photophysical KW - thermal and structural characterization KW - Glycyrrhiza uralensis KW - glycyrol KW - liquiritigenin KW - cholinesterases KW - human monoamine oxidases KW - kinetics KW - docking simulation KW - chalcone KW - neurodegenerative diseases KW - adenosine receptors KW - binding affinity KW - docking KW - 4-hydroxy-7-methoxycoumarin KW - macrophage KW - inflammation KW - NF-κB KW - MAPK KW - calanolides KW - pseudocalanolides KW - calanolide A KW - Calophyllum KW - Calophyllaceae KW - anti-HIV KW - reverse transcriptase KW - non-nucleoside reverse transcriptase inhibitors (NNRTIs) KW - osthole KW - umbelliferone KW - esculin KW - 4-hydroxycoumarin KW - sorafenib KW - apoptosis KW - autophagy KW - Yin Chen Hao KW - constitutive androstane receptor KW - scoparone KW - coumarins KW - quorum sensing KW - QS inhibitors KW - plant-derived molecules KW - Chromobacterium violaceum KW - immunoproteasome KW - psoralen core KW - non-peptidic KW - electrophilic compounds KW - warhead scan KW - inflammatory bowel disease KW - isocoumarin KW - Crohn's disease KW - ulcerative colitis KW - glutathione KW - oxidative stress KW - complementary therapies KW - intestinal inflammation KW - benzopyrones KW - five-membered aromatic heterocycles KW - furan KW - pyrrole KW - thiophene KW - selenophen KW - dihydrocoumarin-fused dihydropyranones KW - 3-aroylcoumarines KW - benzyl 2,3-butadienoate KW - 6'-(4-biphenyl)-β-iso-cinchonine KW - biological applications KW - drug discovery KW - fluorescent probes KW - warfarin KW - acenocoumarol KW - mechanical valve KW - time in therapeutic range KW - anticoagulation KW - Ruta chalepensis KW - Rutaceae KW - chalepin KW - chalepensin KW - bioactivity KW - biosynthesis KW - coumarin3-carboxamides KW - pyranocoumarins KW - anticancer activity KW - antibacterial activity KW - free radical polymerization KW - LED KW - photocomposites KW - direct laser write KW - analytical methods KW - model plant KW - natural genetic variation KW - natural products KW - simple coumarins KW - chalcocoumarin KW - MAO-B KW - molecular dynamics KW - in silico studies KW - dye-sensitized solar cells KW - coumarin dyes KW - thieno [3,2-b] thiophene KW - charge transfer KW - ethynylaryl KW - esculetin KW - antiplatelet activity KW - impedance aggregometry KW - COX KW - polyphenols KW - pyrazole KW - imidazole KW - thiazole KW - oxazole KW - triazole KW - thiadiazole KW - curcumin KW - curcumin-coumarin hybrids KW - neuroprotection KW - monoamine oxidase inhibition KW - cholinesterase inhibition KW - scavenging activity KW - Escherichia coli KW - biotransformation KW - ferulenol KW - structural annotation KW - in silico tools KW - coumarin KW - hydroxyl-modified coumarin KW - photophysical KW - thermal and structural characterization KW - Glycyrrhiza uralensis KW - glycyrol KW - liquiritigenin KW - cholinesterases KW - human monoamine oxidases KW - kinetics KW - docking simulation KW - chalcone KW - neurodegenerative diseases KW - adenosine receptors KW - binding affinity KW - docking KW - 4-hydroxy-7-methoxycoumarin KW - macrophage KW - inflammation KW - NF-κB KW - MAPK KW - calanolides KW - pseudocalanolides KW - calanolide A KW - Calophyllum KW - Calophyllaceae KW - anti-HIV KW - reverse transcriptase KW - non-nucleoside reverse transcriptase inhibitors (NNRTIs) KW - osthole KW - umbelliferone KW - esculin KW - 4-hydroxycoumarin KW - sorafenib KW - apoptosis KW - autophagy KW - Yin Chen Hao KW - constitutive androstane receptor KW - scoparone KW - coumarins KW - quorum sensing KW - QS inhibitors KW - plant-derived molecules KW - Chromobacterium violaceum KW - immunoproteasome KW - psoralen core KW - non-peptidic KW - electrophilic compounds KW - warhead scan KW - inflammatory bowel disease KW - isocoumarin KW - Crohn's disease KW - ulcerative colitis KW - glutathione KW - oxidative stress KW - complementary therapies KW - intestinal inflammation KW - benzopyrones KW - five-membered aromatic heterocycles KW - furan KW - pyrrole KW - thiophene KW - selenophen KW - dihydrocoumarin-fused dihydropyranones KW - 3-aroylcoumarines KW - benzyl 2,3-butadienoate KW - 6'-(4-biphenyl)-β-iso-cinchonine KW - biological applications KW - drug discovery KW - fluorescent probes KW - warfarin KW - acenocoumarol KW - mechanical valve KW - time in therapeutic range KW - anticoagulation KW - Ruta chalepensis KW - Rutaceae KW - chalepin KW - chalepensin KW - bioactivity KW - biosynthesis KW - coumarin3-carboxamides KW - pyranocoumarins KW - anticancer activity KW - antibacterial activity KW - free radical polymerization KW - LED KW - photocomposites KW - direct laser write KW - analytical methods KW - model plant KW - natural genetic variation KW - natural products KW - simple coumarins KW - chalcocoumarin KW - MAO-B KW - molecular dynamics KW - in silico studies KW - dye-sensitized solar cells KW - coumarin dyes KW - thieno [3,2-b] thiophene KW - charge transfer KW - ethynylaryl KW - esculetin KW - antiplatelet activity KW - impedance aggregometry KW - COX KW - polyphenols KW - pyrazole KW - imidazole KW - thiazole KW - oxazole KW - triazole KW - thiadiazole KW - curcumin KW - curcumin-coumarin hybrids KW - neuroprotection KW - monoamine oxidase inhibition KW - cholinesterase inhibition KW - scavenging activity KW - Escherichia coli KW - biotransformation KW - ferulenol KW - structural annotation KW - in silico tools UR - https://www.unicat.be/uniCat?func=search&query=sysid:145803771 AB - Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers. ER -