TY - BOOK ID - 145606281 TI - Computational and Experimental Approaches in Multi-Target Pharmacology PY - 2017 PB - Frontiers Media SA DB - UniCat KW - systems biology KW - computer modeling KW - drug repurposing KW - synergy KW - drug discovery KW - drug combination KW - high throughput screening KW - multidrug therapeutics KW - polypharmacy KW - multifactorial process UR - https://www.unicat.be/uniCat?func=search&query=sysid:145606281 AB - The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics. ER -