TY - BOOK ID - 145513871 TI - mTOR Signaling in Metabolism and Cancer PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - mTOR KW - histone deacetylase KW - prostate cancer KW - integrins KW - adhesion KW - invasion KW - cell metabolism KW - T cells KW - Foxp3 KW - Acute Lymphoblastic leukemia KW - targeted therapy KW - metabolism KW - cell signalling KW - mTOR signalling KW - head and neck cancer KW - mutant genes KW - biomarkers KW - targeted therapies KW - clinical trials KW - cancers KW - inhibitors KW - photodynamic therapy KW - PI3K KW - Akt KW - skin cancers KW - phytochemicals KW - melanoma KW - basal cell carcinoma KW - squamous cell carcinoma KW - Merkel cell carcinoma KW - TNBC KW - eribulin KW - PI3K/AKT/mTOR KW - everolimus KW - combination KW - synergy KW - mTOR signaling KW - tissue regeneration KW - neuron KW - muscle KW - liver KW - intestine KW - hematologic malignancies KW - regulatory T cells KW - tumor KW - mTOR KW - histone deacetylase KW - prostate cancer KW - integrins KW - adhesion KW - invasion KW - cell metabolism KW - T cells KW - Foxp3 KW - Acute Lymphoblastic leukemia KW - targeted therapy KW - metabolism KW - cell signalling KW - mTOR signalling KW - head and neck cancer KW - mutant genes KW - biomarkers KW - targeted therapies KW - clinical trials KW - cancers KW - inhibitors KW - photodynamic therapy KW - PI3K KW - Akt KW - skin cancers KW - phytochemicals KW - melanoma KW - basal cell carcinoma KW - squamous cell carcinoma KW - Merkel cell carcinoma KW - TNBC KW - eribulin KW - PI3K/AKT/mTOR KW - everolimus KW - combination KW - synergy KW - mTOR signaling KW - tissue regeneration KW - neuron KW - muscle KW - liver KW - intestine KW - hematologic malignancies KW - regulatory T cells KW - tumor UR - https://www.unicat.be/uniCat?func=search&query=sysid:145513871 AB - The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases. ER -