TY - BOOK ID - 145367866 TI - Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications AU - Doti, Nunzianna AU - Ruvo, Menotti PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - polymers KW - peptidomimetics KW - AFM KW - transfection KW - molecular modelling KW - peptide KW - α-helix KW - hydrocarbon stapling KW - ring-closing metathesis KW - i,i + 1 staple KW - X-ray structure KW - deferoxamine KW - RGD peptides KW - integrins KW - radiodiagnostics KW - PET imaging KW - retro-inverso peptides KW - anticancer peptides KW - drug delivery KW - peptide antigens KW - Aβ KW - IAPP KW - antimicrobial peptides KW - peptides KW - diagnostic KW - ELISA KW - microarray KW - PET KW - SPECT KW - imaging diagnostic KW - non-imaging diagnostic KW - amphiphilic peptides KW - non-viral gene delivery KW - nanocarrier KW - peptide self-assemblies KW - stimuli responsive KW - SARS-CoV-2 KW - FRET KW - molecular docking KW - molecular dynamics KW - MM-GBSA KW - drug repurposing KW - antiviral KW - cancer KW - cyclic peptide KW - integrin KW - αvβ3 KW - ALOS4 KW - melanoma KW - fluorescent peptide KW - environment-sensitive fluorophore KW - peptide labeling KW - luciferin KW - membrane-binding peptide KW - antimicrobial peptide KW - antitumor peptide KW - RGD peptide KW - antiproliferative activity KW - chirality KW - conformational analysis KW - density functional theory (DFT) KW - ferrocene KW - hydrogen bonds KW - peptidomimetic KW - X-ray KW - protein–protein interactions (PPIs) KW - voltage-gated Na+ (Nav) channels KW - fibroblast growth factor 14 (FGF14) KW - medium spiny neurons (MSNs) KW - nucleus accumbens (NAc) KW - neurotherapeutics KW - cyclophilin A (CypA) KW - apoptosis-inducing factor (AIF) KW - human neuroblastoma SH-SY5Y cells KW - staurosporine-mediated cell death KW - AIF(370-394) peptide KW - caspase-3 KW - PARP KW - antifungal KW - antibacterial KW - peptide-based therapies KW - synthetic peptides KW - polymers KW - peptidomimetics KW - AFM KW - transfection KW - molecular modelling KW - peptide KW - α-helix KW - hydrocarbon stapling KW - ring-closing metathesis KW - i,i + 1 staple KW - X-ray structure KW - deferoxamine KW - RGD peptides KW - integrins KW - radiodiagnostics KW - PET imaging KW - retro-inverso peptides KW - anticancer peptides KW - drug delivery KW - peptide antigens KW - Aβ KW - IAPP KW - antimicrobial peptides KW - peptides KW - diagnostic KW - ELISA KW - microarray KW - PET KW - SPECT KW - imaging diagnostic KW - non-imaging diagnostic KW - amphiphilic peptides KW - non-viral gene delivery KW - nanocarrier KW - peptide self-assemblies KW - stimuli responsive KW - SARS-CoV-2 KW - FRET KW - molecular docking KW - molecular dynamics KW - MM-GBSA KW - drug repurposing KW - antiviral KW - cancer KW - cyclic peptide KW - integrin KW - αvβ3 KW - ALOS4 KW - melanoma KW - fluorescent peptide KW - environment-sensitive fluorophore KW - peptide labeling KW - luciferin KW - membrane-binding peptide KW - antimicrobial peptide KW - antitumor peptide KW - RGD peptide KW - antiproliferative activity KW - chirality KW - conformational analysis KW - density functional theory (DFT) KW - ferrocene KW - hydrogen bonds KW - peptidomimetic KW - X-ray KW - protein–protein interactions (PPIs) KW - voltage-gated Na+ (Nav) channels KW - fibroblast growth factor 14 (FGF14) KW - medium spiny neurons (MSNs) KW - nucleus accumbens (NAc) KW - neurotherapeutics KW - cyclophilin A (CypA) KW - apoptosis-inducing factor (AIF) KW - human neuroblastoma SH-SY5Y cells KW - staurosporine-mediated cell death KW - AIF(370-394) peptide KW - caspase-3 KW - PARP KW - antifungal KW - antibacterial KW - peptide-based therapies KW - synthetic peptides UR - https://www.unicat.be/uniCat?func=search&query=sysid:145367866 AB - This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life. ER -