TY - BOOK ID - 145308455 TI - Role of TCTP in Cell Biological and Disease Processes AU - Bommer, Ulrich-Axel AU - Kawakami, Toshiaki PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - Loxosceles KW - brown spider KW - TCTP KW - venom KW - toxin KW - HRF KW - allergy KW - mast cells KW - basophils KW - IgE KW - FcεRI KW - translationally controlled tumor protein (TCTP) KW - apoptosis KW - conditional knockout mice KW - development KW - Nestin-cre KW - neurogenesis KW - neuronal progenitor cells KW - perinatal death KW - proliferation KW - Mmi1 KW - translationally controlled tumor protein KW - autophagy KW - reactive oxygen species KW - rapamycin KW - nitrogen starvation KW - cancer KW - phospho-TCTP KW - DHA KW - T-DM1 KW - HER2-positive breast cancer KW - TCTP (HRF KW - fortilin) KW - growth and development KW - biological stress reactions KW - regulation of protein synthesis KW - regulated protein degradation KW - cardiovascular diseases UR - https://www.unicat.be/uniCat?func=search&query=sysid:145308455 AB - Translationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP’s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes. ER -