TY - BOOK ID - 145308418 TI - Stem Cell Bioprocessing and Manufacturing AU - Cabral, Joaquim M. S. AU - Lobato da Silva, Cláudia AU - Diogo, Maria Margarida PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - electrospinning KW - live-cell electrospinning KW - tissue engineering KW - cell seeding KW - high voltage KW - viability KW - allogeneic cell therapy KW - induced pluripotent stem cell KW - human embryonic stem cell KW - cell aggregate KW - expansion KW - differentiation KW - scalable manufacturing KW - scale up KW - single-use bioreactor KW - Vertical-Wheel KW - U-shaped vessel KW - computational fluid dynamics KW - shear stress KW - turbulent energy dissipation rates KW - homogeneous hydrodynamic environment KW - human pluripotent stem cells KW - hepatic cell lineages KW - hepatocyte differentiation KW - non-parenchymal liver cells KW - liver organoids KW - disease modeling KW - drug screening KW - olfactory ensheathing cells KW - spinal cord injury KW - neural regeneration KW - cell therapies KW - adipose stem cells KW - neurotrophic factors KW - growth factors KW - peripheral nerve injuries KW - fibrin nerve conduits KW - hydrogels KW - stem cells delivery KW - axonal regeneration KW - Schwann cells KW - stromal vascular fraction KW - stem cell KW - adipose-derived stem cell KW - infrapatellar fat pad KW - knee KW - arthroscopy KW - arthrotomy KW - bioreactor KW - hMSCs KW - microcarrier KW - bioprocess KW - embryonic stem cells KW - mesenchymal stromal cells KW - blood platelets KW - cell culture techniques KW - progenitor cells KW - human adipose stem cells (hASCs) KW - serum- and xeno-free conditions KW - UrSuppe stem cell culture medium KW - autologous therapy KW - kinetic growth modeling KW - segregated and unstructured growth model KW - model predictive control KW - bio-process KW - cell growth KW - lactate KW - advanced therapy medicinal products KW - electrospinning KW - live-cell electrospinning KW - tissue engineering KW - cell seeding KW - high voltage KW - viability KW - allogeneic cell therapy KW - induced pluripotent stem cell KW - human embryonic stem cell KW - cell aggregate KW - expansion KW - differentiation KW - scalable manufacturing KW - scale up KW - single-use bioreactor KW - Vertical-Wheel KW - U-shaped vessel KW - computational fluid dynamics KW - shear stress KW - turbulent energy dissipation rates KW - homogeneous hydrodynamic environment KW - human pluripotent stem cells KW - hepatic cell lineages KW - hepatocyte differentiation KW - non-parenchymal liver cells KW - liver organoids KW - disease modeling KW - drug screening KW - olfactory ensheathing cells KW - spinal cord injury KW - neural regeneration KW - cell therapies KW - adipose stem cells KW - neurotrophic factors KW - growth factors KW - peripheral nerve injuries KW - fibrin nerve conduits KW - hydrogels KW - stem cells delivery KW - axonal regeneration KW - Schwann cells KW - stromal vascular fraction KW - stem cell KW - adipose-derived stem cell KW - infrapatellar fat pad KW - knee KW - arthroscopy KW - arthrotomy KW - bioreactor KW - hMSCs KW - microcarrier KW - bioprocess KW - embryonic stem cells KW - mesenchymal stromal cells KW - blood platelets KW - cell culture techniques KW - progenitor cells KW - human adipose stem cells (hASCs) KW - serum- and xeno-free conditions KW - UrSuppe stem cell culture medium KW - autologous therapy KW - kinetic growth modeling KW - segregated and unstructured growth model KW - model predictive control KW - bio-process KW - cell growth KW - lactate KW - advanced therapy medicinal products UR - https://www.unicat.be/uniCat?func=search&query=sysid:145308418 AB - The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies. ER -