TY - BOOK ID - 145245965 TI - Method Development and Applications for Reduced-Risk Products in Separation Science PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Chemistry KW - Analytical chemistry KW - on!® nicotine pouches KW - nicotine KW - dissolution KW - release profile KW - validation KW - product assessment KW - smokeless tobacco product KW - nicotine degradants KW - nicotine-related impurities KW - alkaloids KW - nicotine degradation products KW - nicotine pouches KW - reduced-risk products KW - constituents KW - method development KW - method validation KW - JUUL KW - aerosol KW - non-targeted analysis KW - chemical characterization KW - ENDS KW - e-cigarette KW - GC-MS KW - LC-HRMS KW - e-liquid KW - 2,4-DNPH derivatization KW - formaldehyde KW - "hidden formaldehyde" KW - formaldehyde-containing hemiacetal/acetal adducts KW - HPHC KW - GC-MS KW - 3-hydroxybenzo[a]pyrene KW - LC-MS/MS KW - urine KW - human biomonitoring KW - derivatization KW - potentially reduced-risk products KW - propylene glycol KW - electronic cigarette KW - biomarker of exposure KW - compliance marker KW - oral tobacco derived nicotine (OTDN) pouches KW - snus KW - nicotine release KW - nicotine dissolution KW - nicotine extraction KW - equivalence KW - modern oral nicotine products KW - HPHCs KW - product characterizations KW - on!® nicotine pouches KW - nicotine KW - dissolution KW - release profile KW - validation KW - product assessment KW - smokeless tobacco product KW - nicotine degradants KW - nicotine-related impurities KW - alkaloids KW - nicotine degradation products KW - nicotine pouches KW - reduced-risk products KW - constituents KW - method development KW - method validation KW - JUUL KW - aerosol KW - non-targeted analysis KW - chemical characterization KW - ENDS KW - e-cigarette KW - GC-MS KW - LC-HRMS KW - e-liquid KW - 2,4-DNPH derivatization KW - formaldehyde KW - "hidden formaldehyde" KW - formaldehyde-containing hemiacetal/acetal adducts KW - HPHC KW - GC-MS KW - 3-hydroxybenzo[a]pyrene KW - LC-MS/MS KW - urine KW - human biomonitoring KW - derivatization KW - potentially reduced-risk products KW - propylene glycol KW - electronic cigarette KW - biomarker of exposure KW - compliance marker KW - oral tobacco derived nicotine (OTDN) pouches KW - snus KW - nicotine release KW - nicotine dissolution KW - nicotine extraction KW - equivalence KW - modern oral nicotine products KW - HPHCs KW - product characterizations UR - https://www.unicat.be/uniCat?func=search&query=sysid:145245965 AB - In recent years, there has been rapid growth in the availability of innovative, non-combustible products, including oral tobacco-derived nicotine (OTDN) products, heated tobacco products (HTPs), and electronic cigarettes (also referred to as e-vapor products; EVPs). Industry, academic, and government researchers are developing and validating analytical methods to extract, separate, identify, and quantitate a variety of analytes from these innovative tobacco products using a wide range of analytical techniques. These analytes include constituents such as nicotine, degradants and impurities, flavors, non-tobacco ingredients, HPHCs, and other currently unknown constituents. In this Special Issue, we received nine contributions that covered the latest analytical methods that have been developed and applied for the chemical characterization or exposure assessment to tobacco product constituents of innovative non-combustible products. This Special Issue is representative of the importance of analytical sciences research in characterizing innovative non-combustible products for guiding product design, determining relative product performance, ensuring consistency during the manufacturing process, informing toxicological risk assessment, and enabling regulatory reporting. The current advances in the development and applications of the analytical methods reported in this Special Issue can be used to inform the harm reduction potential of innovative non-combustible products for adult smokers. ER -