TY - BOOK ID - 145198912 TI - Drug Delivery of siRNA Therapeutics AU - Lamberti, Gaetano AU - Angela Barba, Anna PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - oligonucleotide delivery KW - light-activated release KW - intracellular release KW - liposome KW - indocyanine green KW - drug co-delivery KW - methotrexate KW - siRNA KW - antitumor effect KW - mixed micelles KW - targeted delivery system KW - cationic liposome KW - folate KW - folate receptor KW - cationic cholesterol derivative KW - siRNA delivery KW - gene knockdown KW - tumor-targeting KW - VEGFA KW - VEGFR1 KW - endoglin KW - peptide KW - angiogenesis KW - gene silencing KW - migration KW - proliferation KW - endothelial cells KW - RNAi therapeutics KW - amphiphilic dendrons KW - PAMAM dendrimers KW - self-assembling KW - nanovectors KW - covalent dendrimers KW - NABDs KW - liposomes KW - clinical trials KW - drug delivery KW - nanoparticle KW - carbonate apatite KW - ERBB2 KW - AKT KW - breast cancer KW - ovarian cancer KW - polymer KW - lipid KW - delivery KW - poly(ethylene) imine KW - PEI KW - RNA KW - tyrosine-modification KW - tumor xenograft KW - magnetic nanoparticle KW - iron oxide KW - BCL2 KW - BIRC5/survivin KW - oral cancer KW - aptamers KW - cancer KW - nanoparticles KW - STAT6 KW - polyaspartamide KW - pegylation KW - polyamine KW - polyplexes KW - asthma KW - oligonucleotide delivery KW - light-activated release KW - intracellular release KW - liposome KW - indocyanine green KW - drug co-delivery KW - methotrexate KW - siRNA KW - antitumor effect KW - mixed micelles KW - targeted delivery system KW - cationic liposome KW - folate KW - folate receptor KW - cationic cholesterol derivative KW - siRNA delivery KW - gene knockdown KW - tumor-targeting KW - VEGFA KW - VEGFR1 KW - endoglin KW - peptide KW - angiogenesis KW - gene silencing KW - migration KW - proliferation KW - endothelial cells KW - RNAi therapeutics KW - amphiphilic dendrons KW - PAMAM dendrimers KW - self-assembling KW - nanovectors KW - covalent dendrimers KW - NABDs KW - liposomes KW - clinical trials KW - drug delivery KW - nanoparticle KW - carbonate apatite KW - ERBB2 KW - AKT KW - breast cancer KW - ovarian cancer KW - polymer KW - lipid KW - delivery KW - poly(ethylene) imine KW - PEI KW - RNA KW - tyrosine-modification KW - tumor xenograft KW - magnetic nanoparticle KW - iron oxide KW - BCL2 KW - BIRC5/survivin KW - oral cancer KW - aptamers KW - cancer KW - nanoparticles KW - STAT6 KW - polyaspartamide KW - pegylation KW - polyamine KW - polyplexes KW - asthma UR - https://www.unicat.be/uniCat?func=search&query=sysid:145198912 AB - The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs. ER -