TY - BOOK ID - 145198911 TI - Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment AU - Di Meo, Sergio AU - Venditti, Paola AU - Napolitano, Gaetana PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - Biology, life sciences KW - CTCL KW - apoptosis KW - cell viability KW - c-FLIP KW - XIAP KW - artemisinin KW - SH-SY5Y cells KW - hippocampal neurons KW - H2O2 KW - AMPK pathway KW - atherosclerosis KW - sphingomyelin synthase 2 KW - endothelial dysfunction KW - endoplasmic reticulum stress KW - β-catenin KW - insulin resistance KW - cancer KW - cardiovascular disease KW - neurodegenerative disorders KW - exercise KW - mitochondria KW - oxidative stress KW - PGC-1 KW - Nrf2 KW - UCPs KW - ROS KW - light KW - DNA damage KW - evolution KW - D-box KW - cavefish KW - Spalax KW - trimethylamine N-oxide KW - cardiomyocytes KW - cardiotoxicity KW - mitochondrial membrane potential KW - CORM-2 KW - NADPH oxidase KW - AP-1 KW - HO-1 KW - Renal cell carcinoma (RCC) KW - reactive oxygen species (ROS) KW - glutathione (GSH) metabolism KW - cancer therapy KW - clear cell RCC KW - papillary RCC KW - chromophobe RCC KW - sarcopenia KW - reactive oxygen species KW - redox signaling KW - antioxidant supplementation KW - protein aggregation KW - redox KW - proteinopathy KW - peroxiredoxins KW - tumorigenesis KW - ROS scavengers UR - https://www.unicat.be/uniCat?func=search&query=sysid:145198911 AB - ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging. ER -