TY - BOOK ID - 145177862 TI - Emotional modulation of the synapse AU - Christa McIntyre AU - McIntyre, Christa K. AU - Ploski, Jonathan Eric PY - 2015 PB - Frontiers Media SA DB - UniCat KW - Synapses. KW - Neurology KW - Memory, Long-Term KW - Synapses KW - Brain Stimulation KW - Amygdala KW - BDNF KW - PDE4 KW - reconsolidation KW - Fear conditioning KW - posttraumatic stress disorder KW - ubiquitin-proteasome system KW - CREB KW - extinction KW - Sleep KW - gamma oscillations KW - Research. KW - physiology. KW - Brain Stimulation KW - Amygdala KW - BDNF KW - PDE4 KW - reconsolidation KW - Fear conditioning KW - posttraumatic stress disorder KW - ubiquitin-proteasome system KW - CREB KW - extinction KW - Sleep KW - gamma oscillations UR - https://www.unicat.be/uniCat?func=search&query=sysid:145177862 AB - Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience has produced new insights into the biological mechanisms that determine whether a memory will be stored for the long-term or lost forever. This Research Topic brings together leading experts, who work at multiple levels of analysis, to reveal recent discoveries and concepts regarding the synaptic mechanisms of consolidation and extinction of emotionally arousing memories. ER -