TY - BOOK ID - 145080685 TI - P38 Signaling Pathway AU - Cuenda, Ana AU - Sanz Ezquerro, Juan José PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Research & information: general KW - arginine methylation KW - erythroid differentiation KW - MKK3 KW - phosphorylation, PRMT1 KW - p38 MAPK KW - cocaine KW - conditioned place preference KW - reward KW - stress KW - anxiety KW - depression KW - nucleus accumbens KW - social interaction KW - k opioid receptors KW - p38α KW - Rab5 KW - endosome KW - Alzheimer's KW - Lewy Bodies KW - amyloid-β KW - tau KW - α-synuclein KW - p38-MAPK α inhibitor KW - Alzheimer's disease KW - synaptic plasticity KW - neuroinflammation KW - β-amyloid KW - Tau KW - Kv4.2 KW - seizure KW - temporal lobe epilepsy KW - hippocampus KW - neuronal firing and excitability KW - p38MAPK KW - nuclear translocation KW - β-like importins KW - inflammation KW - cancer KW - skeletal muscle KW - energy metabolism KW - signal transduction KW - exercise KW - type 2 diabetes KW - p38 mitogen-activated protein kinase KW - bleomycin-induced pulmonary fibrosis KW - idiopathic pulmonary fibrosis KW - RNA sequencing KW - alveolar epithelial type II cells KW - MAPK KW - p38 KW - physiology KW - metabolism KW - signaling KW - hypoxia KW - arrhythmia KW - MAPK11 KW - p38β KW - arginine methylation KW - erythroid differentiation KW - MKK3 KW - phosphorylation, PRMT1 KW - p38 MAPK KW - cocaine KW - conditioned place preference KW - reward KW - stress KW - anxiety KW - depression KW - nucleus accumbens KW - social interaction KW - k opioid receptors KW - p38α KW - Rab5 KW - endosome KW - Alzheimer's KW - Lewy Bodies KW - amyloid-β KW - tau KW - α-synuclein KW - p38-MAPK α inhibitor KW - Alzheimer's disease KW - synaptic plasticity KW - neuroinflammation KW - β-amyloid KW - Tau KW - Kv4.2 KW - seizure KW - temporal lobe epilepsy KW - hippocampus KW - neuronal firing and excitability KW - p38MAPK KW - nuclear translocation KW - β-like importins KW - inflammation KW - cancer KW - skeletal muscle KW - energy metabolism KW - signal transduction KW - exercise KW - type 2 diabetes KW - p38 mitogen-activated protein kinase KW - bleomycin-induced pulmonary fibrosis KW - idiopathic pulmonary fibrosis KW - RNA sequencing KW - alveolar epithelial type II cells KW - MAPK KW - p38 KW - physiology KW - metabolism KW - signaling KW - hypoxia KW - arrhythmia KW - MAPK11 KW - p38β UR - https://www.unicat.be/uniCat?func=search&query=sysid:145080685 AB - p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity. ER -